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Comparison of two rapid tests for anti-phenolic glycolipid-I serology in Brazil and Nepal

 Marane Martns de Araújo Stefan ; Adrano Badott Grass ; Samra Bührer-Sékula ; Lnda Oskam ; Sang-Nae ChoV ; Murdo Macdonald ; Deanna A Hagge ; Kapl D Neupane ; Paulne Scheelbeek ; Mauríco Barcelos Costa ; Ana Lúca Osóro Maroclo de Sousa ; Lucas Henrque Sampao 
 Memorias Do Instituto Oswaldo Cruz, Vol.107(Suppl. I) : 124~131, 2012 
Journal Title
 Memorias Do Instituto Oswaldo Cruz 
Issue Date
The diagnosis of leprosy continues to be based on clinical symptoms and early diagnosis and treatment are critical to preventing disability and transmission. Sensitive and specific laboratory tests are not available for diagnosing leprosy. Despite the limited applicability of anti-phenolic glycolipid-I (PGL-I) serology for diagnosis, it has been suggested as an additional tool to classify leprosy patients (LPs) for treatment purposes. Two formats of rapid tests to detect anti-PGL-I antibodies [ML immunochromatography assay (ICA) and ML Flow] were compared in different groups, multibacillary patients, paucibacillary patients, household contacts and healthy controls in Brazil and Nepal. High ML Flow intra-test concordance was observed and low to moderate agreement between the results of ML ICA and ML Flow tests on the serum of LPs was observed. LPs were "seroclassified" according to the results of these tests and the seroclassification was compared to other currently used classification systems: the World Health Organization operational classification, the bacilloscopic index and the Ridley-Jopling classification. When analysing the usefulness of these tests in the operational classification of PB and MB leprosy for treatment and follow-up purposes, the ML Flow test was the best point-of-care test for subjects in Nepal and despite the need for sample dilution, the ML ICA test yielded better performance among Brazilian subjects. Our results identified possible ways to improve the performance of both tests.
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