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Napsin A is an independent prognostic factor in surgically resected adenocarcinoma of the lung.

Authors
 Jin Gu Lee  ;  Sewha Kim  ;  Hyo Sup Shim 
Citation
 LUNG CANCER, Vol.77(1) : 156-161, 2012 
Journal Title
 LUNG CANCER 
ISSN
 0169-5002 
Issue Date
2012
MeSH
Adenocarcinoma/metabolism* ; Adenocarcinoma/mortality ; Adenocarcinoma/pathology ; Adenocarcinoma/surgery ; Adult ; Aged ; Aged, 80 and over ; Aspartic Acid Endopeptidases/genetics ; Aspartic Acid Endopeptidases/metabolism* ; Biomarkers, Tumor/genetics ; Biomarkers, Tumor/metabolism* ; DNA Mutational Analysis ; DNA-Binding Proteins/genetics ; DNA-Binding Proteins/metabolism ; Female ; Gene Expression ; Humans ; Kaplan-Meier Estimate ; Lung Neoplasms/metabolism* ; Lung Neoplasms/mortality ; Lung Neoplasms/pathology ; Lung Neoplasms/surgery ; Male ; Middle Aged ; Multivariate Analysis ; Mutation ; Neoplasm Staging ; Prognosis ; Receptor, Epidermal Growth Factor/genetics ; Transcription Factors ; Tumor Burden
Keywords
Lung ; Adenocarcinoma ; Napsin A ; TTF-1 ; Prognosis
Abstract
INTRODUCTION: Napsin A is regarded as a marker of lung adenocarcinoma. However, no comprehensive analyses of napsin A-positive lung ADCs or the prognostic significance of napsin A expression have been reported to date. METHODS: 110 primary lung adenocarcinoma cases were analyzed for clinicopathologic parameters, including overall survival, stage, histology, napsin A and TTF-1 expression, EGFR mutation, and ALK rearrangement. RESULTS: Napsin A-positive adenocarcinomas were significantly more prevalent among tumors characterized as relatively small (p = 0.023), non-solid predominant (p < 0.001), non-mucinous/enteric (p < 0.001), positive for TTF-1 expression (p < 0.001), and positive for EGFR mutation (p = 0.001). Multivariate analysis of overall survival demonstrated that the absence of napsin A was an independent prognostic factor for reduced survival time (p = 0.002). CONCLUSION: Clinicopathologic characteristics associated with napsin A-positive lung ADC are similar to and overlap with those of TTF-1-positive ADCs. The absence of napsin A is an independent poor prognostic factor in surgically resected adenocarcinoma. Further studies are necessary to determine the role of napsin A in the progression of lung adenocarcinoma.
Full Text
http://www.sciencedirect.com/science/article/pii/S0169500212000736
DOI
22418245
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Thoracic and Cardiovascular Surgery (흉부외과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
Yonsei Authors
Shim, Hyo Sup(심효섭) ORCID logo https://orcid.org/0000-0002-5718-3624
Lee, Jin Gu(이진구)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/91423
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