Cited 29 times in
Napsin A is an independent prognostic factor in surgically resected adenocarcinoma of the lung
DC Field | Value | Language |
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dc.contributor.author | 심효섭 | - |
dc.contributor.author | 이진구 | - |
dc.date.accessioned | 2014-12-19T17:26:47Z | - |
dc.date.available | 2014-12-19T17:26:47Z | - |
dc.date.issued | 2012 | - |
dc.identifier.issn | 0169-5002 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/91423 | - |
dc.description.abstract | INTRODUCTION: Napsin A is regarded as a marker of lung adenocarcinoma. However, no comprehensive analyses of napsin A-positive lung ADCs or the prognostic significance of napsin A expression have been reported to date. METHODS: 110 primary lung adenocarcinoma cases were analyzed for clinicopathologic parameters, including overall survival, stage, histology, napsin A and TTF-1 expression, EGFR mutation, and ALK rearrangement. RESULTS: Napsin A-positive adenocarcinomas were significantly more prevalent among tumors characterized as relatively small (p = 0.023), non-solid predominant (p < 0.001), non-mucinous/enteric (p < 0.001), positive for TTF-1 expression (p < 0.001), and positive for EGFR mutation (p = 0.001). Multivariate analysis of overall survival demonstrated that the absence of napsin A was an independent prognostic factor for reduced survival time (p = 0.002). CONCLUSION: Clinicopathologic characteristics associated with napsin A-positive lung ADC are similar to and overlap with those of TTF-1-positive ADCs. The absence of napsin A is an independent poor prognostic factor in surgically resected adenocarcinoma. Further studies are necessary to determine the role of napsin A in the progression of lung adenocarcinoma. | - |
dc.description.statementOfResponsibility | open | - |
dc.relation.isPartOf | LUNG CANCER | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adenocarcinoma/metabolism* | - |
dc.subject.MESH | Adenocarcinoma/mortality | - |
dc.subject.MESH | Adenocarcinoma/pathology | - |
dc.subject.MESH | Adenocarcinoma/surgery | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Aged, 80 and over | - |
dc.subject.MESH | Aspartic Acid Endopeptidases/genetics | - |
dc.subject.MESH | Aspartic Acid Endopeptidases/metabolism* | - |
dc.subject.MESH | Biomarkers, Tumor/genetics | - |
dc.subject.MESH | Biomarkers, Tumor/metabolism* | - |
dc.subject.MESH | DNA Mutational Analysis | - |
dc.subject.MESH | DNA-Binding Proteins/genetics | - |
dc.subject.MESH | DNA-Binding Proteins/metabolism | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Gene Expression | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Kaplan-Meier Estimate | - |
dc.subject.MESH | Lung Neoplasms/metabolism* | - |
dc.subject.MESH | Lung Neoplasms/mortality | - |
dc.subject.MESH | Lung Neoplasms/pathology | - |
dc.subject.MESH | Lung Neoplasms/surgery | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Multivariate Analysis | - |
dc.subject.MESH | Mutation | - |
dc.subject.MESH | Neoplasm Staging | - |
dc.subject.MESH | Prognosis | - |
dc.subject.MESH | Receptor, Epidermal Growth Factor/genetics | - |
dc.subject.MESH | Transcription Factors | - |
dc.subject.MESH | Tumor Burden | - |
dc.title | Napsin A is an independent prognostic factor in surgically resected adenocarcinoma of the lung | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Thoracic & Cardiovascular Surgery (흉부외과학) | - |
dc.contributor.googleauthor | Jin Gu Lee | - |
dc.contributor.googleauthor | Sewha Kim | - |
dc.contributor.googleauthor | Hyo Sup Shim | - |
dc.identifier.doi | 10.1016/j.lungcan.2012.02.013 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A02219 | - |
dc.contributor.localId | A03225 | - |
dc.relation.journalcode | J02174 | - |
dc.identifier.eissn | 1872-8332 | - |
dc.identifier.pmid | 22418245 | - |
dc.identifier.url | http://www.sciencedirect.com/science/article/pii/S0169500212000736 | - |
dc.subject.keyword | Lung | - |
dc.subject.keyword | Adenocarcinoma | - |
dc.subject.keyword | Napsin A | - |
dc.subject.keyword | TTF-1 | - |
dc.subject.keyword | Prognosis | - |
dc.contributor.alternativeName | Shim, Hyo Sup | - |
dc.contributor.alternativeName | Lee, Jin Gu | - |
dc.contributor.affiliatedAuthor | Shim, Hyo Sup | - |
dc.contributor.affiliatedAuthor | Lee, Jin Gu | - |
dc.citation.volume | 77 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 156 | - |
dc.citation.endPage | 161 | - |
dc.identifier.bibliographicCitation | LUNG CANCER, Vol.77(1) : 156-161, 2012 | - |
dc.identifier.rimsid | 31269 | - |
dc.type.rims | ART | - |
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