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Cited 16 times in

MRI features of hepatocellular carcinoma expressing progenitor cell markers.

DC FieldValueLanguage
dc.contributor.author최기홍-
dc.contributor.author최진섭-
dc.contributor.author김명진-
dc.contributor.author김여은-
dc.contributor.author박영년-
dc.date.accessioned2014-12-19T17:26:15Z-
dc.date.available2014-12-19T17:26:15Z-
dc.date.issued2012-
dc.identifier.issn1478-3223-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/91406-
dc.description.abstractBACKGROUND & AIMS: To determine whether magnetic resonance (MR) imaging features differ between hepatocellular carcinomas (HCCs) with and without expression of progenitor cell markers, such as cytokeratin (CK) 19 and epithelial cell adhesion molecule (EpCAM). METHODS: Sixty-three patients with 71 HCCs who underwent surgery after preoperative gadoxetic acid-enhanced MR imaging were evaluated. HCCs expressing progenitor cell markers were defined as showing CK19 or EpCAM expression. MR imaging features, including the fat component, arterial enhancement (global vs. peripheral), dynamic enhancement (washout vs. progressive or persistent), nodule-in-nodule appearance and MR gross morphology (expanding vs. non-expanding), were compared between HCCs with and without progenitor cell markers expression. Lesion-to-liver signal intensity ratio (SIR) and apparent diffusion coefficient values were compared using an independent samples t-test. Early recurrence rates were also compared. RESULTS: HCCs expressing progenitor cell markers were more commonly of the non-expanding type (P = 0.016), more frequently had a progressive or persistent dynamic enhancement pattern (P = 0.008) and less frequently demonstrated a nodule-in-nodule appearance (P = 0.009). HCCs expressing progenitor cell markers had significantly higher SIRs on diffusion-weighted images (DWIs) (b = 50 and 800, P < 0.001; b = 400, P = 0.001) and a significantly lower SIR on hepatobiliary phase images (P = 0.024). The early recurrence rate was significantly higher in patients with prior HCCs that expressed progenitor cell markers (P = 0.045). CONCLUSIONS: HCCs expressing progenitor cell markers can be characterized according to their non-expanding MR gross morphology, persistent or progressive dynamic enhancement patterns, higher SIRs on DWIs, lower SIRs on hepatobiliary phase images and less frequent nodule-in-nodule appearance.-
dc.description.statementOfResponsibilityopen-
dc.relation.isPartOfLiver International-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdult-
dc.subject.MESHAged-
dc.subject.MESHAntigens, Neoplasm/metabolism-
dc.subject.MESHBiomarkers, Tumor/metabolism*-
dc.subject.MESHCarcinoma, Hepatocellular/diagnosis*-
dc.subject.MESHCarcinoma, Hepatocellular/metabolism-
dc.subject.MESHCarcinoma, Hepatocellular/pathology*-
dc.subject.MESHCell Adhesion Molecules/metabolism-
dc.subject.MESHEpithelial Cell Adhesion Molecule-
dc.subject.MESHFemale-
dc.subject.MESHHumans-
dc.subject.MESHImage Processing, Computer-Assisted-
dc.subject.MESHKeratin-19/metabolism-
dc.subject.MESHLiver/cytology-
dc.subject.MESHLiver Neoplasms/diagnosis*-
dc.subject.MESHLiver Neoplasms/metabolism-
dc.subject.MESHLiver Neoplasms/pathology*-
dc.subject.MESHMagnetic Resonance Imaging-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHRecurrence-
dc.subject.MESHStem Cells/metabolism-
dc.titleMRI features of hepatocellular carcinoma expressing progenitor cell markers.-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Radiology (영상의학)-
dc.contributor.googleauthorHyeon Tae Jeong-
dc.contributor.googleauthorMyeong-Jin Kim-
dc.contributor.googleauthorYeo-Eun Kim-
dc.contributor.googleauthorYoung Nyun Park-
dc.contributor.googleauthorGi Hong Choi-
dc.contributor.googleauthorJin Sub Choi-
dc.identifier.doi22097930-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA04046-
dc.contributor.localIdA04199-
dc.contributor.localIdA00426-
dc.contributor.localIdA00688-
dc.contributor.localIdA01563-
dc.relation.journalcodeJ02171-
dc.identifier.pmid22097930-
dc.identifier.urlhttp://onlinelibrary.wiley.com/doi/10.1111/j.1478-3231.2011.02640.x/abstract-
dc.subject.keywordhepatocellular carcinomass-
dc.subject.keywordmagneticresonance imaging-
dc.subject.keywordprogenitor cell markers-
dc.contributor.alternativeNameChoi, Gi Hong-
dc.contributor.alternativeNameChoi, Jin Sub-
dc.contributor.alternativeNameKim, Myeong Jin-
dc.contributor.alternativeNameKim, Yeo Eun-
dc.contributor.alternativeNamePark, Young Nyun-
dc.contributor.affiliatedAuthorChoi, Gi Hong-
dc.contributor.affiliatedAuthorChoi, Jin Sub-
dc.contributor.affiliatedAuthorKim, Myeong Jin-
dc.contributor.affiliatedAuthorKim, Yeo Eun-
dc.contributor.affiliatedAuthorPark, Young Nyun-
dc.citation.volume32-
dc.citation.number3-
dc.citation.startPage430-
dc.citation.endPage440-
dc.identifier.bibliographicCitationLiver International, Vol.32(3) : 430-440, 2012-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers

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