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전립선암의 호르몬 불응성과 PTEN, CD44발현 양상의 연관성 분석

Other Titles
 The Analysis of Relationship between Refractoriness to Androgen Deprivation and PTEN, CD44 Expression in Prostate Cancer 
 함원식  ;  박재원  ;  조강수  ;  이창기  ;  최영득  ;  홍성준 
 Korean Journal of Urological Oncology (대한비뇨기종양학술지), Vol.10(1) : 21-26, 2012 
Journal Title
 Korean Journal of Urological Oncology  (대한비뇨기종양학술지) 
Issue Date
Purpose: Most prostate cancers (PCs) ultimately progress to castration resistant prostate cancer (CRPC) after androgen deprivation therapy (ADT). Because cancer stem cells survive ADT, which can lead to tumor recurrence and understanding the molecular changes that occur after ADT would helpful for finding novel therapies targeting CRPC, we analyzed the expression of CD44, a stem cell marker in radical prostatectomy samples after ADT. Materials and Methods: PTEN and CD44 expression profiles were determined by microarray or real-time PCR in 107 radical prostatectomy specimens from patients given neoadjuvant ADT. Pathological regressive changes and the correlation of postoperative biochemical failure with PTEN and CD44 expression were analyzed. Results: As the PC tissues had minimal regression effects after ADT, they showed significantly advanced pathological stage (p=0.001), PTEN inactivation (p<0.001), and high CD44 expression (p<0.001). The PTEN inactivation group showed a significantly higher probability of positive CD44 expression compared to the non-PTEN inactivation group (OR 10.5, 95% CI 4.0 to 27.6, p<0.001). Cox regression analysis revealed that seminal vesicle invasion, biopsy Gleason score, and CD44 expression were significantly associated with the time to biochemical recurrence. Conclusions: PC tissues refractory to ADT showed PTEN inactivation with high CD44 expression. The PTEN inactivation group showed a significantly high probability of positive CD44 expression. Our results support that the PTEN/PI3K/Akt pathways are necessary for prostate cancer stem cell maintenance.
Appears in Collections:
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Urology (비뇨의학교실)
Yonsei Authors
조강수(Cho, Kang Su) ; 최영득(Choi, Young Deuk) ; 함원식(Ham, Won Sik) ; 홍성준(Hong, Sung Joon)
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