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Hepatic cavernous hemangiomas: relationship between speed of intratumoral enhancement during dynamic MRI and apparent diffusion coefficient on diffusion-weighted imaging.

 Se Jin Nam  ;  Kae Young Park  ;  Jeong-Sik Yu  ;  Jae-Joon Chung  ;  Joo Hee Kim  ;  Ki Whang Kim 
 KOREAN JOURNAL OF RADIOLOGY, Vol.13(6) : 728-735, 2012 
Journal Title
Issue Date
Adult ; Aged ; Contrast Media ; Diffusion Magnetic Resonance Imaging* ; Female ; Gadolinium DTPA ; Hemangioma, Cavernous/diagnosis* ; Humans ; Image Enhancement ; Liver Neoplasms/diagnosis* ; Magnetic Resonance Imaging* ; Male ; Middle Aged
Diffusion-weighted MR imaging ; Hemangioma ; Liver, MR ; Liver, neoplasms
OBJECTIVE: To investigate the relationships between the apparent diffusion coefficients (ADCs) on diffusion-weighted imaging (DWI) and the speed of contrast-enhancement in hepatic hemangiomas. MATERIALS AND METHODS: Sixty-nine hepatic hemangiomas (≥ 1 cm) were evaluated with DWI, by using multiple b values (b = 50, 400, 800 s/mm(2)), followed by a gadolinium-enhanced dynamic MRI. The lesions were classified into three groups, according to the speed of contrast-enhancement on the portal phase. ADCs were measured on the ADC map automatically, and were calculated by using the two different b values (mADC(50-400) with b values = 50 and 400; mADC(400-800) with b values = 400 and 800 s/mm(2)). RESULTS: The mean ADCs (× 10(-3) mm(2)/s) were significantly higher in the rapid group (1.9 ± 0.44) than in the intermediate (1.7 ± 0.35, p = 0.046) or the slow groups (1.4 ± 0.34, p = 0.002). There were significant differences between the rapid and the slow groups in mADC(50-400) (2.12 vs. 1.48; p = 0.008) and mADC(400-800) (1.68 vs. 1.22, p = 0.010), and between the rapid and the intermediate groups in mADC(50-400) (2.12 vs. 1.79, p = 0.049). Comparing mADC(50-400) with mADC(400-800), there was a significant difference only in the rapid group (p = 0.001). CONCLUSION: Higher ADCs of rapidly-enhancing hemangiomas may be related to richer intralesional vascular perfusion. Also, the restricted diffusion may be attributed to the difference of structural characteristics of hemangioma.
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1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
Yonsei Authors
Kim, Ki Whang(김기황)
Kim, Joo Hee(김주희) ORCID logo https://orcid.org/0000-0001-5383-3602
Yu, Jeong Sik(유정식) ORCID logo https://orcid.org/0000-0002-8171-5838
Chung, Jae Joon(정재준) ORCID logo https://orcid.org/0000-0002-7447-1193
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