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Effects of Human Mesenchymal Stem Cell Transplantation Combined with Polymer on Functional Recovery Following Spinal Cord Hemisection in Rats

 Ji Soo Choi  ;  Joong Woo Leem  ;  Kyung Hee Lee  ;  Sung-Soo Kim  ;  Haeyoung Suh-Kim  ;  Se Jung Jung  ;  Un Jeng Kim  ;  Bae Hwan Lee 
 Korean Journal of Physiology & Pharmacology, Vol.16(6) : 405-411, 2012 
Journal Title
 Korean Journal of Physiology & Pharmacology 
Issue Date
The spontaneous axon regeneration of damaged neurons is limited after spinal cord injury (SCI). Recently, mesenchymal stem cell (MSC) transplantation was proposed as a potential approach for enhancing nerve regeneration that avoids the ethical issues associated with embryonic stem cell transplantation. As SCI is a complex pathological entity, the treatment of SCI requires a multipronged approach. The purpose of the present study was to investigate the functional recovery and therapeutic potential of human MSCs (hMSCs) and polymer in a spinal cord hemisection injury model. Rats were subjected to hemisection injuries and then divided into three groups. Two groups of rats underwent partial thoracic hemisection injury followed by implantation of either polymer only or polymer with hMSCs. Another hemisection-only group was used as a control. Behavioral, electrophysiological and immunohistochemical studies were performed on all rats. The functional recovery was significantly improved in the polymer with hMSC-transplanted group as compared with control at five weeks after transplantation. The results of electrophysiologic study demonstrated that the latency of somatosensoryevoked potentials (SSEPs) in the polymer with hMSC-transplanted group was significantly shorter than in the hemisection-only control group. In the results of immunohistochemical study, β-gal-positive cells were observed in the injured and adjacent sites after hMSC transplantation. Surviving hMSCs differentiated into various cell types such as neurons, astrocytes and oligodendrocytes. These data suggest that hMSC transplantation with polymer may play an important role in functional recovery and axonal regeneration after SCI, and may be a potential therapeutic strategy for SCI.
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1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원)
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Physiology (생리학교실)
Yonsei Authors
김은정(Kim, Un Jeng) ORCID logo https://orcid.org/0000-0003-0968-0252
이배환(Lee, Bae Hwan) ORCID logo https://orcid.org/0000-0003-4719-9021
임중우(Leem, Joong Woo) ORCID logo https://orcid.org/0000-0002-1605-2230
정세정(Jung, Se Jung)
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