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Rosai-Dorfman Disease in the breast with increased IgG4 expressing plasma cells: a case report

Authors
 Yoon Jin Cha  ;  Woo Ick Yang  ;  Se Ho Park  ;  Ja Seung Koo 
Citation
 KOREAN JOURNAL OF PATHOLOGY , Vol.46(5) : 489-493, 2012 
Journal Title
 KOREAN JOURNAL OF PATHOLOGY 
ISSN
 1738-1843 
Issue Date
2012
Keywords
Breast ; Histiocytosis ; Histiocytosis, sinus ; Immunoglobulin G
Abstract
Rosai-Dorfman disease (RDD) can present in any anatomic site, but breast involvement is rarely reported. Recently, a relationship between RDD and IgG4-related sclerosing disease has been suggested. Here we report another case of RDD with overlapping features of IgG4-related sclerosing disease occurring in a right breast of a 62-year-old female. On microscopic examination, the mass demonstrated a characteristic zonal pattern of proliferation of large polygonal histiocytes and lymphoplasma cells with stromal fibrosis. Emperipolesis was observed in histiocytes with abundant cytoplasm, which showed immunoreactivity for S-100 protein and CD68; the diagnosis of RDD was made. Sheets of plasma cells in the fibrotic stroma demonstrated positive reactions for IgG and IgG4. The mean count of IgG4-positive plasma cells was 100.2/high power field, and the ratio of IgG4/IgG was 56.7%. Additional findings of stromal fibrosis and obliteration of preexisting breast lobules suggested overlapping features with IgG4-related sclerosing disease.
Files in This Item:
T201203952.pdf Download
DOI
23136577
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
Yonsei Authors
Koo, Ja Seung(구자승) ORCID logo https://orcid.org/0000-0003-4546-4709
Park, Se Ho(박세호) ORCID logo https://orcid.org/0000-0001-8089-2755
Yang, Woo Ick(양우익) ORCID logo https://orcid.org/0000-0002-6084-5019
Cha, Yoon Jin(차윤진) ORCID logo https://orcid.org/0000-0002-5967-4064
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/91315
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