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Rosai-Dorfman Disease in the breast with increased IgG4 expressing plasma cells: a case report

 Yoon Jin Cha  ;  Woo Ick Yang  ;  Se Ho Park  ;  Ja Seung Koo 
 Korean Journal of Pathology, Vol.46(5) : 489-493, 2012 
Journal Title
 Korean Journal of Pathology 
Issue Date
Rosai-Dorfman disease (RDD) can present in any anatomic site, but breast involvement is rarely reported. Recently, a relationship between RDD and IgG4-related sclerosing disease has been suggested. Here we report another case of RDD with overlapping features of IgG4-related sclerosing disease occurring in a right breast of a 62-year-old female. On microscopic examination, the mass demonstrated a characteristic zonal pattern of proliferation of large polygonal histiocytes and lymphoplasma cells with stromal fibrosis. Emperipolesis was observed in histiocytes with abundant cytoplasm, which showed immunoreactivity for S-100 protein and CD68; the diagnosis of RDD was made. Sheets of plasma cells in the fibrotic stroma demonstrated positive reactions for IgG and IgG4. The mean count of IgG4-positive plasma cells was 100.2/high power field, and the ratio of IgG4/IgG was 56.7%. Additional findings of stromal fibrosis and obliteration of preexisting breast lobules suggested overlapping features with IgG4-related sclerosing disease.
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1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실)
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실)
Yonsei Authors
구자승(Koo, Ja Seung) ORCID logo https://orcid.org/0000-0003-4546-4709
박세호(Park, Se Ho) ORCID logo https://orcid.org/0000-0001-8089-2755
양우익(Yang, Woo Ick) ORCID logo https://orcid.org/0000-0002-6084-5019
차윤진(Cha, Yoon Jin) ORCID logo https://orcid.org/0000-0002-5967-4064
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