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Efficacy and toxicity of belotecan for relapsed or refractory small cell lung cancer patients

Authors
 Kim, Gun Min  ;  Kim, Young Sam  ;  Kang, Young Ae  ;  Jeong, Jae-Heon  ;  Kim, Sun Mi  ;  Hong, Yun Kyoung  ;  Sung, Ji Hee  ;  Lim, Seung Taek  ;  Kim, Joo Hang  ;  Kim, Se Kyu  ;  Cho, Byoung Chul 
Citation
 Journal of Thoracic Oncology, Vol.7(4) : 731-736, 2012 
Journal Title
 Journal of Thoracic Oncology 
ISSN
 1556-0864 
Issue Date
2012
Abstract
INTRODUCTION: Belotecan (Camtobell, CKD602) is a new camptothecin-derivative antitumor agent that belongs to the topoisomerase inhibitors. The aim of this study was to evaluate the efficacy and safety of belotecan monotherapy as a second-line therapy in patients with relapsed or refractory small cell lung cancer (SCLC). METHODS: Between June 2008 and August 2011, a total of 50 patients with relapsed or refractory SCLC were treated with belotecan 0.5 mg/m for 5 consecutive days, every 3 weeks. We evaluated the overall response rate (ORR), the progression-free survival (PFS), and the overall survival (OS), and toxicity according to sensitivity to initial chemotherapy. RESULTS: The median age was 66 years (range, 43-84 years) and Eastern Cooperative Oncology Group performance was 0 or 1 in 34 patients (68%) and 2 in 16 patients (32%). Twenty patients (40%) had sensitive relapse and 30 patients (60%) had refractory disease. The ORR, PFS, and OS for sensitive patients were 20% (95% confidence interval [CI], 8-40), 2.8 months (95% CI, 0.53-5.06), and 6.5 months (95% CI, 1.58-11.42), respectively. In the refractory group, the ORR, PFS, and OS were 10% (95% CI, 1-21), 1.5 months (95% CI, 1.25-1.75), and 4.0 months (95% CI, 3.40-4.60), respectively. Most commonly reported grade-3 or -4 adverse events included neutropenia (54%), thrombocytopenia (38%), and anemia (32%). CONCLUSION: Belotecan showed modest activity with an acceptable safety profile as a second-line therapy in patients with relapsed or refractory SCLC.
Full Text
http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&AN=01243894-201204000-00014&LSLINK=80&D=ovft
DOI
10.1097/JTO.0b013e31824b23cb
Appears in Collections:
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실)
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원)
Yonsei Authors
강영애(Kang, Young Ae) ORCID logo https://orcid.org/0000-0002-7783-5271
김건민(Kim, Gun Min) ORCID logo https://orcid.org/0000-0001-9167-8682
김선미(Kim, Sun Mi)
김세규(Kim, Se Kyu)
김영삼(Kim, Young Sam) ORCID logo https://orcid.org/0000-0001-9656-8482
김주항(Kim, Joo Hang)
임승택(Lim, Seung Taek)
조병철(Cho, Byoung Chul) ORCID logo https://orcid.org/0000-0002-5562-270X
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URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/91173
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