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Antiarrhythmic potential of mesenchymal stem cell is modulated by hypoxic environment.
DC Field | Value | Language |
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dc.contributor.author | 박희남 | - |
dc.contributor.author | 차민지 | - |
dc.contributor.author | 송병욱 | - |
dc.contributor.author | 최은주 | - |
dc.contributor.author | 심재민 | - |
dc.contributor.author | 함온주 | - |
dc.contributor.author | 이문형 | - |
dc.contributor.author | 황기철 | - |
dc.contributor.author | 이세연 | - |
dc.contributor.author | 황혜진 | - |
dc.contributor.author | 임소연 | - |
dc.contributor.author | 김성순 | - |
dc.contributor.author | 장양수 | - |
dc.contributor.author | 김일권 | - |
dc.contributor.author | 정보영 | - |
dc.date.accessioned | 2014-12-19T17:16:53Z | - |
dc.date.available | 2014-12-19T17:16:53Z | - |
dc.date.issued | 2012 | - |
dc.identifier.issn | 0735-1097 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/91117 | - |
dc.description.abstract | OBJECTIVES: The purpose of this study was to evaluate the antiarrhythmic potential of mesenchymal stem cells (MSC) under a different environment. BACKGROUND: Little is known about how environmental status affects antiarrhythmic potential of MSCs. METHODS: To investigate the effect of paracrine factors secreted from MSCs under different circumstances on arrhythmogenicity in rats with myocardial infarction, we injected paracrine media (PM) secreted under hypoxic, normoxic conditions (hypoxic PM and normoxic PM), and MSC into the border zone of infarcted myocardium in rats. RESULTS: We found that the injection of hypoxic PM, but not normoxic PM, markedly restored conduction velocities, suppressed focal activity, and prevented sudden arrhythmic deaths in rats. Underlying this electrophysiological alteration was a decrease in fibrosis, restoration of connexin 43, alleviation of Ca(2+) overload, and recovery of Ca(2+)-regulatory ion channels and proteins, all of which is supported by proteomic data showing that several paracrine factors including basic fibroblast growth factor, insulinlike growth factor 1, hepatocyte growth factor, and EF-hand domain-containing 2 are potential mediators. When compared with PM, MSC injection did not reduce or prevent arrhythmogenicity, suggesting that the antiarrhythmic or proarrhythmic potential of MSC is mainly dependent on paracrine factors. CONCLUSIONS: A hypoxic or normoxic environment surrounding MSC affects the type and properties of the growth factors or cytokines, and these secreted molecules determine the characteristics of the electro-anatomical substrate of the surrounding myocardium. | - |
dc.description.statementOfResponsibility | open | - |
dc.relation.isPartOf | JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Arrhythmias, Cardiac/metabolism | - |
dc.subject.MESH | Arrhythmias, Cardiac/physiopathology | - |
dc.subject.MESH | Arrhythmias, Cardiac/surgery* | - |
dc.subject.MESH | Disease Models, Animal | - |
dc.subject.MESH | Hypoxia/metabolism | - |
dc.subject.MESH | Hypoxia/physiopathology | - |
dc.subject.MESH | Hypoxia/therapy* | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Mesenchymal Stem Cell Transplantation/methods* | - |
dc.subject.MESH | Myocardium/metabolism* | - |
dc.subject.MESH | Myocardium/pathology | - |
dc.subject.MESH | Rats | - |
dc.subject.MESH | Rats, Sprague-Dawley | - |
dc.title | Antiarrhythmic potential of mesenchymal stem cell is modulated by hypoxic environment. | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Life Science (의생명과학부) | - |
dc.contributor.googleauthor | Hye Jin Hwang | - |
dc.contributor.googleauthor | Woochul Chang | - |
dc.contributor.googleauthor | Byeong-Wook Song | - |
dc.contributor.googleauthor | Heesang Song | - |
dc.contributor.googleauthor | Min-Ji Cha | - |
dc.contributor.googleauthor | Il-Kwon Kim | - |
dc.contributor.googleauthor | Soyeon Lim | - |
dc.contributor.googleauthor | Eun Ju Choi | - |
dc.contributor.googleauthor | Onju Ham | - |
dc.contributor.googleauthor | Se-Yeon Lee | - |
dc.contributor.googleauthor | Jaemin Shim | - |
dc.contributor.googleauthor | Boyoung Joung | - |
dc.contributor.googleauthor | Hui-Nam Pak | - |
dc.contributor.googleauthor | Sung Soon Kim | - |
dc.contributor.googleauthor | Bum-Rak Choi | - |
dc.contributor.googleauthor | Yangsoo Jang | - |
dc.contributor.googleauthor | Moon-Hyoung Lee | - |
dc.contributor.googleauthor | Ki-Chul Hwang | - |
dc.identifier.doi | 22999735 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A01776 | - |
dc.contributor.localId | A03995 | - |
dc.contributor.localId | A02026 | - |
dc.contributor.localId | A04160 | - |
dc.contributor.localId | A02206 | - |
dc.contributor.localId | A04336 | - |
dc.contributor.localId | A02766 | - |
dc.contributor.localId | A04456 | - |
dc.contributor.localId | A02880 | - |
dc.contributor.localId | A04496 | - |
dc.contributor.localId | A00573 | - |
dc.contributor.localId | A03448 | - |
dc.contributor.localId | A03609 | - |
dc.contributor.localId | A00848 | - |
dc.contributor.localId | A03373-1 | - |
dc.relation.journalcode | J01770 | - |
dc.identifier.eissn | 1558-3597 | - |
dc.identifier.pmid | 22999735 | - |
dc.identifier.url | http://www.sciencedirect.com/science/article/pii/S0735109712029300 | - |
dc.subject.keyword | arrhythmia | - |
dc.subject.keyword | mesenchymal stem cells | - |
dc.subject.keyword | myocardial infarction | - |
dc.subject.keyword | paracrine factors | - |
dc.contributor.alternativeName | Pak, Hui Nam | - |
dc.contributor.alternativeName | Cha, Min Ji | - |
dc.contributor.alternativeName | Song, Byeong Wook | - |
dc.contributor.alternativeName | Choi, Eun Ju | - |
dc.contributor.alternativeName | Shim, Jae Min | - |
dc.contributor.alternativeName | Ham, On Ju | - |
dc.contributor.alternativeName | Lee, Moon Hyoung | - |
dc.contributor.alternativeName | Hwang, Ki Chul | - |
dc.contributor.alternativeName | Lee, Se Yeon | - |
dc.contributor.alternativeName | Hwang, Hye Jin | - |
dc.contributor.alternativeName | Lim, So Yeon | - |
dc.contributor.alternativeName | Kim, Sung Soon | - |
dc.contributor.alternativeName | Jang, Yang Soo | - |
dc.contributor.alternativeName | Kim, Il Kwon | - |
dc.contributor.alternativeName | Joung, Bo Young | - |
dc.contributor.affiliatedAuthor | Pak, Hui Nam | - |
dc.contributor.affiliatedAuthor | Cha, Min Ji | - |
dc.contributor.affiliatedAuthor | Song, Byeong Wook | - |
dc.contributor.affiliatedAuthor | Choi, Eun Ju | - |
dc.contributor.affiliatedAuthor | Shim, Jae Min | - |
dc.contributor.affiliatedAuthor | Ham, On Ju | - |
dc.contributor.affiliatedAuthor | Lee, Moon Hyoung | - |
dc.contributor.affiliatedAuthor | Hwang, Ki Chul | - |
dc.contributor.affiliatedAuthor | Lee, Se Yeon | - |
dc.contributor.affiliatedAuthor | Hwang, Hye Jin | - |
dc.contributor.affiliatedAuthor | Kim, Sung Soon | - |
dc.contributor.affiliatedAuthor | Jang, Yang Soo | - |
dc.contributor.affiliatedAuthor | Joung, Bo Young | - |
dc.contributor.affiliatedAuthor | Kim, Il Kwon | - |
dc.contributor.affiliatedAuthor | Lim, So Yeon | - |
dc.citation.volume | 60 | - |
dc.citation.number | 17 | - |
dc.citation.startPage | 1698 | - |
dc.citation.endPage | 1706 | - |
dc.identifier.bibliographicCitation | JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, Vol.60(17) : 1698-1706, 2012 | - |
dc.identifier.rimsid | 33926 | - |
dc.type.rims | ART | - |
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