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Elevated high-sensitivity C-reactive protein, a marker of advanced stage gastric cancer and postgastrectomy disease recurrence

Authors
 Yanghee Woo  ;  Woo Jin Hyung  ;  Kazutaka Obama  ;  Hyoung-Il Kim  ;  Kyung Ho Pak  ;  Taeil Son  ;  Sung Hoon Noh 
Citation
 JOURNAL OF SURGICAL ONCOLOGY, Vol.105(4) : 405-409, 2012 
Journal Title
 JOURNAL OF SURGICAL ONCOLOGY 
ISSN
 0022-4790 
Issue Date
2012
MeSH
Biomarkers, Tumor/metabolism* ; C-Reactive Protein/metabolism* ; Female ; Follow-Up Studies ; Gastrectomy/adverse effects* ; Humans ; Lymph Node Excision ; Lymphatic Metastasis ; Male ; Middle Aged ; Neoplasm Recurrence, Local/diagnosis* ; Neoplasm Recurrence, Local/metabolism* ; Neoplasm Recurrence, Local/mortality ; Neoplasm Staging ; Postoperative Complications* ; Preoperative Care ; Prognosis ; Prospective Studies ; Risk Factors ; Stomach Neoplasms/metabolism* ; Stomach Neoplasms/mortality ; Stomach Neoplasms/surgery ; Survival Rate
Keywords
gastric cancer recurrence ; hs-CRP ; and biomarker
Abstract
BACKGROUND AND OBJECTIVES: Gastric cancer recurrence after curative surgery remains high. Although no preoperative marker of gastric cancer progression after radical gastrectomy exists, recent studies suggest that C-reactive protein (CRP) is associated with cancer progression. Our study evaluated the significance of preoperative high-sensitivity CRP (hs-CRP) levels as a marker of disease progression after radical gastrectomy. METHODS: The preoperative hs-CRP levels of 1,221 gastric cancer patients who underwent radical gastrectomies were analyzed for clinicopathologic significance. Patients with previous gastric cancer treatment, another primary cancer, active infection, or postoperative mortality were excluded. RESULTS: hs-CRP levels were significantly associated with increased tumor depth (P = 0.028), nodal status (P = 0.012), and stage (P = 0.045). Seventeen percent of patients had elevated hs-CRP levels at the cutoff value of >3.00 mg/L, whereas 6.6% and 6.1% of patients had CEA and CA-19-9 levels about the cutoffs of ≥5.00 ng/ml and ≥35.0 U/L, respectively. Hs-CRP levels >3.00 mg/L were an independent risk factor for recurrence-free survival along with stage. CONCLUSION: Elevated preoperative hs-CRP levels in gastric cancer patients are clinically significant indicators of advanced stage and postoperative disease recurrence.
Full Text
http://onlinelibrary.wiley.com/doi/10.1002/jso.22129/abstract
DOI
22025360
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Hyoung Il(김형일) ORCID logo https://orcid.org/0000-0002-6134-4523
Noh, Sung Hoon(노성훈) ORCID logo https://orcid.org/0000-0003-4386-6886
Pak, Kyung Ho(박경호)
Son, Tae Il(손태일) ORCID logo https://orcid.org/0000-0002-0327-5224
Hyung, Woo Jin(형우진) ORCID logo https://orcid.org/0000-0002-8593-9214
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/91102
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