2 175

Cited 0 times in

Effect of vitamin E on oxidative stress in the contralateral testis of neonatal and pubertal hemicastrated rats

Authors
 Woong Kyu Han  ;  Mei Hua Jin  ;  Sang Won Han 
Citation
 JOURNAL OF PEDIATRIC UROLOGY, Vol.8(1) : 67-71, 2012 
Journal Title
 JOURNAL OF PEDIATRIC UROLOGY 
ISSN
 1477-5131 
Issue Date
2012
MeSH
Administration, Oral ; Animals ; Animals, Newborn ; Antioxidants/pharmacology ; Catalase/drug effects ; Catalase/metabolism ; Disease Models, Animal ; Glutathione Reductase/drug effects ; Glutathione Reductase/metabolism ; Lipid Peroxidation/drug effects ; Male ; Orchiectomy/methods* ; Oxidative Stress/drug effects* ; Oxidative Stress/physiology ; Random Allocation ; Rats ; Rats, Sprague-Dawley ; Reference Values ; Sensitivity and Specificity ; Sexual Maturation ; Superoxide Dismutase/drug effects ; Superoxide Dismutase/metabolism* ; Vitamin E/pharmacology*
Keywords
TestisOxidative stressAntioxidants
Abstract
OBJECTIVE: To evaluate whether the antioxidant vitamin E can prevent the harmful effects of reactive oxidative stress (ROS) that occur during compensatory testicular hypertrophy (CTH). MATERIALS AND METHODS: Thirty Sprague-Dawley rats were divided into six equal groups: neonatal hemicastrated vitamin E (NH_Vit E/NH) and sham surgical controls (NC), and pubertal hemicastrated vitamin E (PH_Vit E/PH) and sham surgical controls (PC). Vitamin E was administered orally to the NH_Vit E and PH_Vit E groups three times a week from week 3-12 prior to sacrifice. Antioxidant enzymes were measured in testis samples from each animal. RESULTS: Differences in superoxide dismutase activity were observed between the NH (21.04 ± 0.48) and NH_Vit E (22.62 ± 0.64) groups (P = 0.008); the PH (20.59 ± 0.11) and PC (20.91 ± 0.20) groups (P = 0.032); and the PH (20.59 ± 0.11) and PH_Vit E (22.32 ± 1.01) groups (P = 0.008). Thiobarbituric acid-reactive substance in the PH and PH_Vit E groups was 0.097 ± 0.022 and 0.036 ± 0.004 (P = 0.008), respectively; and in the NH and NH_Vit E groups it was 0.135 ± 0.02 and 0.039 ± 0.003 (P = 0.008), respectively. CONCLUSIONS: These results suggest that CTH is not associated with reducing oxidative injury, nor does it prevent ROS-induced cell damage. However, administration of vitamin E does reduce oxidative injury and prevent ROS-induced cell damage in a hemicastrated rat model.
Full Text
http://www.sciencedirect.com/science/article/pii/S1477513110004912
DOI
21093379
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Urology (비뇨의학교실) > 1. Journal Papers
Yonsei Authors
Han, Sang Won(한상원) ORCID logo https://orcid.org/0000-0003-0941-1300
Han, Woong Kyu(한웅규) ORCID logo https://orcid.org/0000-0002-2527-4046
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/91039
사서에게 알리기
  feedback

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse