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Effect of vitamin E on oxidative stress in the contralateral testis of neonatal and pubertal hemicastrated rats
DC Field | Value | Language |
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dc.contributor.author | 한상원 | - |
dc.contributor.author | 한웅규 | - |
dc.date.accessioned | 2014-12-19T17:14:22Z | - |
dc.date.available | 2014-12-19T17:14:22Z | - |
dc.date.issued | 2012 | - |
dc.identifier.issn | 1477-5131 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/91039 | - |
dc.description.abstract | OBJECTIVE: To evaluate whether the antioxidant vitamin E can prevent the harmful effects of reactive oxidative stress (ROS) that occur during compensatory testicular hypertrophy (CTH). MATERIALS AND METHODS: Thirty Sprague-Dawley rats were divided into six equal groups: neonatal hemicastrated vitamin E (NH_Vit E/NH) and sham surgical controls (NC), and pubertal hemicastrated vitamin E (PH_Vit E/PH) and sham surgical controls (PC). Vitamin E was administered orally to the NH_Vit E and PH_Vit E groups three times a week from week 3-12 prior to sacrifice. Antioxidant enzymes were measured in testis samples from each animal. RESULTS: Differences in superoxide dismutase activity were observed between the NH (21.04 ± 0.48) and NH_Vit E (22.62 ± 0.64) groups (P = 0.008); the PH (20.59 ± 0.11) and PC (20.91 ± 0.20) groups (P = 0.032); and the PH (20.59 ± 0.11) and PH_Vit E (22.32 ± 1.01) groups (P = 0.008). Thiobarbituric acid-reactive substance in the PH and PH_Vit E groups was 0.097 ± 0.022 and 0.036 ± 0.004 (P = 0.008), respectively; and in the NH and NH_Vit E groups it was 0.135 ± 0.02 and 0.039 ± 0.003 (P = 0.008), respectively. CONCLUSIONS: These results suggest that CTH is not associated with reducing oxidative injury, nor does it prevent ROS-induced cell damage. However, administration of vitamin E does reduce oxidative injury and prevent ROS-induced cell damage in a hemicastrated rat model. | - |
dc.description.statementOfResponsibility | open | - |
dc.relation.isPartOf | JOURNAL OF PEDIATRIC UROLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Administration, Oral | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Animals, Newborn | - |
dc.subject.MESH | Antioxidants/pharmacology | - |
dc.subject.MESH | Catalase/drug effects | - |
dc.subject.MESH | Catalase/metabolism | - |
dc.subject.MESH | Disease Models, Animal | - |
dc.subject.MESH | Glutathione Reductase/drug effects | - |
dc.subject.MESH | Glutathione Reductase/metabolism | - |
dc.subject.MESH | Lipid Peroxidation/drug effects | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Orchiectomy/methods* | - |
dc.subject.MESH | Oxidative Stress/drug effects* | - |
dc.subject.MESH | Oxidative Stress/physiology | - |
dc.subject.MESH | Random Allocation | - |
dc.subject.MESH | Rats | - |
dc.subject.MESH | Rats, Sprague-Dawley | - |
dc.subject.MESH | Reference Values | - |
dc.subject.MESH | Sensitivity and Specificity | - |
dc.subject.MESH | Sexual Maturation | - |
dc.subject.MESH | Superoxide Dismutase/drug effects | - |
dc.subject.MESH | Superoxide Dismutase/metabolism* | - |
dc.subject.MESH | Vitamin E/pharmacology* | - |
dc.title | Effect of vitamin E on oxidative stress in the contralateral testis of neonatal and pubertal hemicastrated rats | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Urology (비뇨기과학) | - |
dc.contributor.googleauthor | Woong Kyu Han | - |
dc.contributor.googleauthor | Mei Hua Jin | - |
dc.contributor.googleauthor | Sang Won Han | - |
dc.identifier.doi | 21093379 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A04285 | - |
dc.contributor.localId | A04308 | - |
dc.relation.journalcode | J01691 | - |
dc.identifier.eissn | 1873-4898 | - |
dc.identifier.pmid | 21093379 | - |
dc.identifier.url | http://www.sciencedirect.com/science/article/pii/S1477513110004912 | - |
dc.subject.keyword | TestisOxidative stressAntioxidants | - |
dc.contributor.alternativeName | Han, Sang Won | - |
dc.contributor.alternativeName | Han, Woong Kyu | - |
dc.contributor.affiliatedAuthor | Han, Sang Won | - |
dc.contributor.affiliatedAuthor | Han, Woong Kyu | - |
dc.citation.volume | 8 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 67 | - |
dc.citation.endPage | 71 | - |
dc.identifier.bibliographicCitation | JOURNAL OF PEDIATRIC UROLOGY, Vol.8(1) : 67-71, 2012 | - |
dc.identifier.rimsid | 33295 | - |
dc.type.rims | ART | - |
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