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In vivo characteristics of Korean Beijing Mycobacterium tuberculosis strain K1 in an aerosol challenge model and in the Cornell latent tuberculosis model

Authors
 Bo-Young Jeon  ;  Jeongyeon Kwak  ;  Mi-Young Hahn  ;  Seok-Yong Eum  ;  Jiyeon Yang  ;  Seung-Cheol Kim  ;  Sang-Nae Cho 
Citation
 JOURNAL OF MEDICAL MICROBIOLOGY, Vol.61(Part 10) : 1373-1379, 2012 
Journal Title
 JOURNAL OF MEDICAL MICROBIOLOGY 
ISSN
 0022-2615 
Issue Date
2012
MeSH
Aerosols ; Animals ; Cytokines/genetics ; Cytokines/metabolism ; Disease Models, Animal ; Disease Outbreaks ; Female ; Gene Expression Regulation/immunology ; Humans ; Lung/immunology ; Lung/microbiology ; Lung/pathology ; Mice ; Mice, Inbred C57BL ; Mycobacterium tuberculosis/classification ; Mycobacterium tuberculosis/physiology* ; Recurrence ; Republic of Korea/epidemiology ; Specific Pathogen-Free Organisms ; Spleen/microbiology ; Transcriptome ; Tuberculosis, Pulmonary/epidemiology ; Tuberculosis, Pulmonary/microbiology* ; Tuberculosis, Pulmonary/pathology
Keywords
Aerosols ; Animals ; Cytokines/genetics ; Cytokines/metabolism ; Disease Models, Animal ; Disease Outbreaks ; Female ; Gene Expression Regulation/immunology ; Humans ; Lung/immunology ; Lung/microbiology ; Lung/pathology ; Mice ; Mice, Inbred C57BL ; Mycobacterium tuberculosis/classification ; Mycobacterium tuberculosis/physiology* ; Recurrence ; Republic of Korea/epidemiology ; Specific Pathogen-Free Organisms ; Spleen/microbiology ; Transcriptome ; Tuberculosis, Pulmonary/epidemiology ; Tuberculosis, Pulmonary/microbiology* ; Tuberculosis, Pulmonary/pathology
Abstract
The Beijing Mycobacterium tuberculosis family is widely distributed and is the most common M. tuberculosis strain in East Asia. The highly transmissible and predominant Beijing M. tuberculosis strain in Korea, M. tuberculosis K1, was characterized using an aerobic challenge mouse model and a latent tuberculosis model with M. tuberculosis H37Rv as a reference. M. tuberculosis K1 multiplied over ten times more rapidly than M. tuberculosis H37Rv during the early stage of infection and induced high levels of histopathology in the lung. Low levels of T helper cell (Th) Th1 [interferon (IFN)-γ, interleukin (IL)-12p40] and Th2 cytokines (IL-4, IL-10) were induced in the lungs of M. tuberculosis K1-infected mice. In the latent model, mice infected with M. tuberculosis K1 exhibited more frequent relapse from the latent state than did mice infected with M. tuberculosis H37Rv. In conclusion, M. tuberculosis K1, a prevalent Beijing strain in Korea, is expected to spread due to its rapid growth during the early stages of infection, low-level induction of the immune response and high relapse rates from a latent state.
Full Text
http://jmm.sgmjournals.org/content/61/Pt_10/1373.short
DOI
22820694
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Microbiology (미생물학교실) > 1. Journal Papers
Yonsei Authors
Cho, Sang Nae(조상래)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/90962
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