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Comparison of lipid-related ratios for prediction of chronic kidney disease stage 3 or more in Korean adults

 Ji-Young Kim  ;  Hee-Taik Kang  ;  Hye-Ree Lee  ;  Yong-Jae Lee  ;  Jae-Yong Shim 
 Journal of Korean Medical Science, Vol.27(12) : 1524-1529, 2012 
Journal Title
 Journal of Korean Medical Science 
Issue Date
Adult ; Aged ; Asian Continental Ancestry Group ; Cholesterol/blood* ; Cholesterol, HDL/blood* ; Cholesterol, LDL/blood* ; Cross-Sectional Studies ; Female ; Glomerular Filtration Rate ; Humans ; Male ; Middle Aged ; Nutrition Surveys ; Odds Ratio ; Predictive Value of Tests ; Prevalence ; Renal Insufficiency, Chronic/epidemiology ; Renal Insufficiency, Chronic/etiology ; Renal Insufficiency, Chronic/metabolism* ; Republic of Korea ; Risk Factors ; Severity of Illness Index* ; Triglycerides/blood*
Dyslipidemias ; Glomerular Filtration Rate ; Kidney Failure, Chronic
Dyslipidemia is implicated in increased cardiovascular risk associated with chronic kidney disease (CKD) and in the progression of renal damage. This study compared 4 different lipid-related ratios (total cholesterol [TC]/high-density lipoprotein cholesterol [HDL-C], triglyceride [TG]/HDL-C, calculated low-density lipoprotein cholesterol [c-LDL-C]/HDL-C, and non-HDL-C/HDL-C ratio) for prediction of CKD stage 3 or more to investigate the association between them. This cross-sectional study included 8,650 adults who participated in the 2007-2008 Korean National Health and Nutrition Examination Survey. The overall prevalence of CKD stage 3 or more was 6.4%. For TG/HDL-C, the prevalence with CKD stage 3 or more increased with increasing quartile group in both sexes (P value for trend = 0.046 in men, 0.002 in women) while other lipid-related ratios showed increasing prevalence only in women. In comparison with the lowest quartile of the lipid-related ratios, only the fourth quartile of TG/HDL-C was associated with the prevalence of CKD stage 3 or more in both sexes after adjustment for multiple covariates (odds ratio [OR] for TG/HDL-C-Q(4), 1.82; 95% CI [confidence interval], 1.09-3.03 in men, OR 2.45; 95% CI, 1.52-3.95 in women). In conclusion, TG/HDL-C is the only lipid-related ratio that is independently associated with CKD stage 3 or more in both sexes of Koreans.
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1. College of Medicine (의과대학) > Dept. of Family Medicine (가정의학교실) > 1. Journal Papers
Yonsei Authors
Kang, Hee Taik(강희택)
Kim, Ji Young(김지영)
Shim, Jae Yong(심재용) ORCID logo https://orcid.org/0000-0002-9561-9230
Lee, Yong Jae(이용제) ORCID logo https://orcid.org/0000-0002-6697-476X
Lee, Hye Ree(이혜리)
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