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Optical coherence tomography evaluation of in-stent restenotic lesions with visible microvessels

 Byeong-Keuk Kim  ;  Jung-Sun Kim  ;  Dong-Ho Shin  ;  Young-Guk Ko  ;  Donghoon Choi  ;  Yangsoo Jang  ;  Myeong-Ki Hong 
 JOURNAL OF INVASIVE CARDIOLOGY, Vol.24(3) : 116-120, 2012 
Journal Title
Issue Date
Aged ; Angioplasty, Balloon, Coronary ; Coronary Restenosis/pathology* ; Coronary Stenosis/therapy ; Coronary Vessels/pathology* ; Drug-Eluting Stents* ; Female ; Humans ; Logistic Models ; Male ; Microvessels/pathology* ; Middle Aged ; Neointima/pathology ; ROC Curve ; Stents* ; Tomography, Optical Coherence/methods*
optical coherence tomography ; restenosis ; stent
OBJECTIVE: We sought to evaluate the characteristics of in-stent restenosis (ISR) lesions with microvessels, detected by an optical coherence tomography (OCT). BACKGROUND: No sufficient in vivo data exist regarding microvessel characteristics in ISR lesions. METHODS: Among 78 ISR lesions (drug-eluting stent, n = 72; bare-metal stent, n = 6) in our OCT registry database, visible microvessels were detected in 21 (27%). Microvessels were defined as low backscattering structures <200 μm in diameter on OCT. Clinical, angiographic, and OCT findings were compared between lesions with and without microvessels. RESULTS: Lesions with microvessels had a larger reference vessel diameter (2.90 ± 0.47 mm vs 2.58 ± 0.42 mm; P=.009) and post-stent minimum lumen diameter (2.76 ± 0.29 mm vs 2.54 ± 0.39 mm; P=.033) than those without microvessels. From OCT findings at the segment with minimal lumen cross-sectional area (CSA), neointimal hyperplasia (NIH) CSA (5.4 ± 1.7 mm² vs 4.2 ± 2.1 mm²; P=.024) and percent NIH CSA (NIH CSA x 100/stent CSA) were significantly greater in lesions with microvessels (79 ± 12% vs 67 ± 16%; P=.001). On multivariate analysis, reference vessel diameter (odds ratio [OR], 4.64; 95% confidence interval [CI], 1.05-20.4; P=.043) and percent NIH CSA at the segment with minimal lumen CSA (OR, 1.06; 95% CI, 1.01-1.12; P=.021) were independent predictors of microvessels. From receiver operating characteristic analysis, the cut-off values of reference vessel diameter and percent NIH CSA predicting the presence of microvessels were 3.1 mm and 74%, respectively. CONCLUSIONS: Visible microvessels in ISR lesions might be associated with increased vessel size and extent of NIH.
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1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Ko, Young Guk(고영국) ORCID logo https://orcid.org/0000-0001-7748-5788
Kim, Byeong Keuk(김병극) ORCID logo https://orcid.org/0000-0003-2493-066X
Kim, Jung Sun(김중선) ORCID logo https://orcid.org/0000-0003-2263-3274
Shin, Dong Ho(신동호) ORCID logo https://orcid.org/0000-0002-7874-5542
Jang, Yang Soo(장양수) ORCID logo https://orcid.org/0000-0002-2169-3112
Choi, Dong Hoon(최동훈) ORCID logo https://orcid.org/0000-0002-2009-9760
Hong, Myeong Ki(홍명기) ORCID logo https://orcid.org/0000-0002-2090-2031
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