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Potential contribution of preoperative neoadjuvant concurrent chemoradiation therapy on margin-negative resection in borderline resectable pancreatic cancer

DC FieldValueLanguage
dc.contributor.author정용은-
dc.contributor.author최혜진-
dc.contributor.author강창무-
dc.contributor.author황호경-
dc.contributor.author김현기-
dc.contributor.author박정엽-
dc.contributor.author성진실-
dc.contributor.author송시영-
dc.contributor.author이우정-
dc.date.accessioned2014-12-19T17:07:39Z-
dc.date.available2014-12-19T17:07:39Z-
dc.date.issued2012-
dc.identifier.issn1091-255X-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/90827-
dc.description.abstractBACKGROUND: Margin-negative pancreatectomy provides only chance to cure pancreatic cancer. However, borderline resectable pancreatic cancer (BRPCa) has the risk of incomplete palliative resection. MATERIALS AND METHODS: We retrospectively reviewed 32 patients with BRPCa who underwent a pancreatectomy following preoperative chemoradiation therapy (CCRT (+)/Px group) and compared these patients with those with resectable pancreatic cancer (RPCa) who underwent pancreatectomy without preoperative CCRT (CCRT (-)/Px group, n=104). RESULTS: Eighteen patients (56.2%) showed more than 50% significant pathological response to CCRT. The degree of pathological responses showed a positive relationship between final pT stage (p=0.075). More frequent vascular resection (p<0.001), transfusion (p=0.076), and longer operation time were observed in the CCRT(+)/Px group. However, similar R0 resection rates (p=0.272), lower pT stage (p<0.001), smaller number of metastastic lymph nodes (p=0.002), and lower incidence of lymph node metastasis (p=0.032) were noted in the CCRT(+)/Px group. The overall disease-specific survival were similar (median survival, 30.5 months (95% CI; 23.6-37.4) vs. 26.3 months (95% CI; 15.9-36.7), p=0.709), and no statistical differences in cancer recurrence risks were noted between the two groups (p=0.505). CONCLUSION: Pancreatectomy following preoperative neoadjuvant CCRT can be a potential strategy for margin-negative resection in BRPCa patients.-
dc.description.statementOfResponsibilityopen-
dc.relation.isPartOfJOURNAL OF GASTROINTESTINAL SURGERY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdenocarcinoma/pathology*-
dc.subject.MESHAdenocarcinoma/therapy-
dc.subject.MESHAntineoplastic Agents/therapeutic use*-
dc.subject.MESHChemoradiotherapy-
dc.subject.MESHFemale-
dc.subject.MESHFollow-Up Studies-
dc.subject.MESHHumans-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHNeoadjuvant Therapy-
dc.subject.MESHNeoplasm Staging-
dc.subject.MESHPancreatectomy*-
dc.subject.MESHPancreatic Neoplasms/pathology-
dc.subject.MESHPancreatic Neoplasms/therapy*-
dc.subject.MESHPreoperative Care/methods*-
dc.subject.MESHRetrospective Studies-
dc.subject.MESHTreatment Outcome-
dc.titlePotential contribution of preoperative neoadjuvant concurrent chemoradiation therapy on margin-negative resection in borderline resectable pancreatic cancer-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Radiation Oncology (방사선종양학)-
dc.contributor.googleauthorChang Moo Kang-
dc.contributor.googleauthorYong Eun Chung-
dc.contributor.googleauthorJeong Youp Park-
dc.contributor.googleauthorJin Sil Sung-
dc.contributor.googleauthorHo Kyoung Hwang-
dc.contributor.googleauthorHye Jin Choi-
dc.contributor.googleauthorHyunki Kim-
dc.contributor.googleauthorSi Young Song-
dc.contributor.googleauthorWoo Jung Lee-
dc.identifier.doi22183861-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA03662-
dc.contributor.localIdA04219-
dc.contributor.localIdA00088-
dc.contributor.localIdA04497-
dc.contributor.localIdA01108-
dc.contributor.localIdA01647-
dc.contributor.localIdA01956-
dc.contributor.localIdA02035-
dc.contributor.localIdA02993-
dc.relation.journalcodeJ01418-
dc.identifier.eissn1873-4626-
dc.identifier.pmid22183861-
dc.identifier.urlhttp://link.springer.com/article/10.1007%2Fs11605-011-1784-3-
dc.subject.keywordNeoadjuvant-
dc.subject.keywordChemoradiation-
dc.subject.keywordPancreatic cancer-
dc.subject.keywordBorderline resectable-
dc.contributor.alternativeNameChung, Yong Eun-
dc.contributor.alternativeNameChoi, Hye Jin-
dc.contributor.alternativeNameKang, Chang Moo-
dc.contributor.alternativeNameHwang, Ho Kyoung-
dc.contributor.alternativeNameKim, Hyun Ki-
dc.contributor.alternativeNamePark, Jeong Youp-
dc.contributor.alternativeNameSeong, Jin Sil-
dc.contributor.alternativeNameSong, Si Young-
dc.contributor.alternativeNameLee, Woo Jung-
dc.contributor.affiliatedAuthorChung, Yong Eun-
dc.contributor.affiliatedAuthorChoi, Hye Jin-
dc.contributor.affiliatedAuthorKang, Chang Moo-
dc.contributor.affiliatedAuthorHwang, Ho Kyoung-
dc.contributor.affiliatedAuthorKim, Hyun Ki-
dc.contributor.affiliatedAuthorPark, Jeong Youp-
dc.contributor.affiliatedAuthorSeong, Jin Sil-
dc.contributor.affiliatedAuthorSong, Si Young-
dc.contributor.affiliatedAuthorLee, Woo Jung-
dc.citation.volume16-
dc.citation.number3-
dc.citation.startPage509-
dc.citation.endPage517-
dc.identifier.bibliographicCitationJOURNAL OF GASTROINTESTINAL SURGERY, Vol.16(3) : 509-517, 2012-
dc.identifier.rimsid33559-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Radiation Oncology (방사선종양학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers

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