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Metabolic syndrome is an independent risk factor for synchronous colorectal neoplasm in patients with gastric neoplasm

Authors
 Wan Park  ;  Hyuk Lee  ;  Eun Hye Kim  ;  Ji Young Yoon  ;  Jun Chul Park  ;  Sung Kwan Shin  ;  Sang Kil Lee  ;  Yong Chan Lee  ;  Won Ho Kim  ;  Sung Hoon Noh 
Citation
 Journal of Gastroenterology and Hepatology, Vol.27(9) : 1490-1497, 2012 
Journal Title
 Journal of Gastroenterology and Hepatology 
ISSN
 0815-9319 
Issue Date
2012
MeSH
Adenocarcinoma/epidemiology* ; Adenoma/epidemiology* ; Adult ; Aged ; Aged, 80 and over ; Case-Control Studies ; Colonoscopy ; Colorectal Neoplasms/epidemiology* ; Confidence Intervals ; Cross-Sectional Studies ; Female ; Humans ; Logistic Models ; Male ; Metabolic Syndrome/epidemiology* ; Middle Aged ; Multivariate Analysis ; Neoplasms, Multiple Primary/epidemiology* ; Odds Ratio ; Prevalence ; Retrospective Studies ; Risk Assessment ; Risk Factors ; Stomach Neoplasms/epidemiology*
Keywords
colonoscopy ; colorectal neoplasm ; gastric neoplasm ; metabolic syndrome ; screening
Abstract
BACKGROUND AND AIM: There are no data on how metabolic syndrome (MetS) affects the prevalence of synchronous colorectal neoplasm (CRN) in gastric neoplasm (GN) patients. The aim of this study was to investigate a model for risk stratification for colorectal screening by evaluating the clinical characteristics of synchronous CRN in GN patients classified according to the presence of MetS. METHODS: A cross-sectional, case-control study of 492 patients (368 males and 124 females) with GN, and 492 age-matched healthy controls undergoing simultaneous upper endoscopy and colonoscopy, was conducted. RESULTS: The GN group involved 446 patients without MetS, and 46 patients with MetS. In total, 177 (39.7%) and 28 (60.9%) synchronous CRN were detected in GN patients without MetS and with MetS, respectively (P=0.006). A total of 143 (34.7%) synchronous colorectal adenomas were detected in GN patients without MetS, whereas 17 (48.6%) were detected in GN patients with MetS (P=0.101), as well as more synchronous colorectal cancers (11.2% vs 37.9%, P<0.001). A multivariate logistic regression analysis revealed that the presence of GN (OR=1.54, 95% CI: 1.18-2.00, P=0.001) and the presence of MetS (odds ratio=1.82, 95% confidence interval: 1.19-2.78, P=0.006) were significant independent risk factors associated with the prevalence of CRN. The frequency of synchronous CRN in GN patients with MetS was 1.96 times greater than that in the GN group without MetS. CONCLUSION: The risk of synchronous CRN is significantly increased by the presence of GN, especially in MetS patients. Screening for synchronous CRN is highly recommended for GN patients with MetS.
Full Text
http://onlinelibrary.wiley.com/doi/10.1111/j.1440-1746.2012.07128.x/abstract
DOI
22432868
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Won Ho(김원호) ORCID logo https://orcid.org/0000-0002-5682-9972
Kim, Eun Hye(김은혜) ORCID logo https://orcid.org/0000-0001-6691-6837
Noh, Sung Hoon(노성훈) ORCID logo https://orcid.org/0000-0003-4386-6886
Park, Wan(박완)
Park, Jun Chul(박준철) ORCID logo https://orcid.org/0000-0001-8018-0010
Shin, Sung Kwan(신성관) ORCID logo https://orcid.org/0000-0001-5466-1400
Yun, Gi Young(윤지영)
Lee, Sang Kil(이상길) ORCID logo https://orcid.org/0000-0002-0721-0364
Lee, Yong Chan(이용찬) ORCID logo https://orcid.org/0000-0001-8800-6906
Lee, Hyuk(이혁)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/90818
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