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Clinical features and outcomes of primary hepatic neuroendocrine carcinomas

 Chan Hyuk Park  ;  Joo Won Chung  ;  Seon Jung Jang  ;  Moon Jae Chung  ;  Seungmin Bang  ;  Seung Woo Park  ;  Si Young Song  ;  Jae Bock Chung  ;  Jeong Youp Park 
 Journal of Gastroenterology and Hepatology, Vol.27(8) : 1306-1311, 2012 
Journal Title
 Journal of Gastroenterology and Hepatology 
Issue Date
Adult ; Aged ; Aged, 80 and over ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Biopsy ; Carcinoma, Neuroendocrine/diagnosis* ; Carcinoma, Neuroendocrine/mortality ; Carcinoma, Neuroendocrine/pathology ; Carcinoma, Neuroendocrine/therapy* ; Chemoembolization, Therapeutic ; Chemotherapy, Adjuvant ; Female ; Hepatectomy ; Humans ; Kaplan-Meier Estimate ; Liver Neoplasms/diagnosis* ; Liver Neoplasms/mortality ; Liver Neoplasms/pathology ; Liver Neoplasms/therapy* ; Male ; Middle Aged ; Neoadjuvant Therapy ; Predictive Value of Tests ; Retrospective Studies ; Time Factors ; Tomography, X-Ray Computed ; Treatment Outcome
carcinoid tumor ; carcinoma ; neuroendocrine ; neuroendocrine tumors
BACKGROUND AND AIM: Primary hepatic neuroendocrine carcinomas (PHNECs) are extremely rare, with only about 150 cases having been reported in the English-language literature. Because of the rarity of PHNECs, its clinical features and treatment outcomes are not well understood. Here, we report our experiences with PHNECs. METHODS: We identified patients diagnosed with PHNEC and analyzed their demographics, baseline laboratory data, tumor characteristics, treatment modalities and outcomes. RESULTS: A total of 218 consecutive patients were identified with pathologically confirmed neuroendocrine carcinoma. Of these, 12 patients were diagnosed with PHNECs; the median age was 66.5 years (range, 37 to 80 years), and seven patients (58.3%) were male. Two patients who each had a single hepatic mass underwent curative surgical resection. One patient who was of inoperable status at the initial diagnosis because of multiple intrahepatic metastases showed a partial response after the ninth round of systemic chemotherapy and then underwent surgical resection. The median overall survival in the 12 patients was 16.5 months (range, 0.7 to 41.7 months). Three patients who underwent surgical treatment are alive without recurrence for 15.2 months, 18.0 months, and 36.9 months, respectively. CONCLUSIONS: Primary hepatic neuroendocrine carcinoma should be considered as a possible differential diagnosis in the management of hepatic tumors. The liver can be the primary origin of neuroendocrine tumors, and if the tumors are diagnosed as primary hepatic neuroendocrine tumors, surgical resection must be considered for curative treatment.
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1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Park, Seung Woo(박승우) ORCID logo https://orcid.org/0000-0001-8230-964X
Park, Jeong Youp(박정엽) ORCID logo https://orcid.org/0000-0003-0110-8606
Park, Chan Hyuk(박찬혁)
Bang, Seungmin(방승민) ORCID logo https://orcid.org/0000-0001-5209-8351
Song, Si Young(송시영) ORCID logo https://orcid.org/0000-0002-1417-4314
Chung, Moon Jae(정문재) ORCID logo https://orcid.org/0000-0002-5920-8549
Chung, Jae Bock(정재복)
Chung, Joo Won(정주원)
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