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Clinical features and outcomes of primary hepatic neuroendocrine carcinomas

DC Field Value Language
dc.contributor.author송시영-
dc.contributor.author정문재-
dc.contributor.author정재복-
dc.contributor.author정주원-
dc.contributor.author박승우-
dc.contributor.author박정엽-
dc.contributor.author박찬혁-
dc.contributor.author방승민-
dc.date.accessioned2014-12-19T17:07:19Z-
dc.date.available2014-12-19T17:07:19Z-
dc.date.issued2012-
dc.identifier.issn0815-9319-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/90817-
dc.description.abstractBACKGROUND AND AIM: Primary hepatic neuroendocrine carcinomas (PHNECs) are extremely rare, with only about 150 cases having been reported in the English-language literature. Because of the rarity of PHNECs, its clinical features and treatment outcomes are not well understood. Here, we report our experiences with PHNECs. METHODS: We identified patients diagnosed with PHNEC and analyzed their demographics, baseline laboratory data, tumor characteristics, treatment modalities and outcomes. RESULTS: A total of 218 consecutive patients were identified with pathologically confirmed neuroendocrine carcinoma. Of these, 12 patients were diagnosed with PHNECs; the median age was 66.5 years (range, 37 to 80 years), and seven patients (58.3%) were male. Two patients who each had a single hepatic mass underwent curative surgical resection. One patient who was of inoperable status at the initial diagnosis because of multiple intrahepatic metastases showed a partial response after the ninth round of systemic chemotherapy and then underwent surgical resection. The median overall survival in the 12 patients was 16.5 months (range, 0.7 to 41.7 months). Three patients who underwent surgical treatment are alive without recurrence for 15.2 months, 18.0 months, and 36.9 months, respectively. CONCLUSIONS: Primary hepatic neuroendocrine carcinoma should be considered as a possible differential diagnosis in the management of hepatic tumors. The liver can be the primary origin of neuroendocrine tumors, and if the tumors are diagnosed as primary hepatic neuroendocrine tumors, surgical resection must be considered for curative treatment.-
dc.description.statementOfResponsibilityopen-
dc.format.extent1306~1311-
dc.relation.isPartOfJOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdult-
dc.subject.MESHAged-
dc.subject.MESHAged, 80 and over-
dc.subject.MESHAntineoplastic Combined Chemotherapy Protocols/therapeutic use-
dc.subject.MESHBiopsy-
dc.subject.MESHCarcinoma, Neuroendocrine/diagnosis*-
dc.subject.MESHCarcinoma, Neuroendocrine/mortality-
dc.subject.MESHCarcinoma, Neuroendocrine/pathology-
dc.subject.MESHCarcinoma, Neuroendocrine/therapy*-
dc.subject.MESHChemoembolization, Therapeutic-
dc.subject.MESHChemotherapy, Adjuvant-
dc.subject.MESHFemale-
dc.subject.MESHHepatectomy-
dc.subject.MESHHumans-
dc.subject.MESHKaplan-Meier Estimate-
dc.subject.MESHLiver Neoplasms/diagnosis*-
dc.subject.MESHLiver Neoplasms/mortality-
dc.subject.MESHLiver Neoplasms/pathology-
dc.subject.MESHLiver Neoplasms/therapy*-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHNeoadjuvant Therapy-
dc.subject.MESHPredictive Value of Tests-
dc.subject.MESHRetrospective Studies-
dc.subject.MESHTime Factors-
dc.subject.MESHTomography, X-Ray Computed-
dc.subject.MESHTreatment Outcome-
dc.titleClinical features and outcomes of primary hepatic neuroendocrine carcinomas-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Internal Medicine (내과학)-
dc.contributor.googleauthorChan Hyuk Park-
dc.contributor.googleauthorJoo Won Chung-
dc.contributor.googleauthorSeon Jung Jang-
dc.contributor.googleauthorMoon Jae Chung-
dc.contributor.googleauthorSeungmin Bang-
dc.contributor.googleauthorSeung Woo Park-
dc.contributor.googleauthorSi Young Song-
dc.contributor.googleauthorJae Bock Chung-
dc.contributor.googleauthorJeong Youp Park-
dc.identifier.doi22414232-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA02035-
dc.contributor.localIdA03602-
dc.contributor.localIdA03706-
dc.contributor.localIdA03726-
dc.contributor.localIdA01551-
dc.contributor.localIdA01647-
dc.contributor.localIdA01711-
dc.contributor.localIdA01786-
dc.relation.journalcodeJ01417-
dc.identifier.eissn1440-1746-
dc.identifier.pmid22414232-
dc.identifier.urlhttp://onlinelibrary.wiley.com/doi/10.1111/j.1440-1746.2012.07117.x/abstract-
dc.subject.keywordcarcinoid tumor-
dc.subject.keywordcarcinoma-
dc.subject.keywordneuroendocrine-
dc.subject.keywordneuroendocrine tumors-
dc.contributor.alternativeNameSong, Si Young-
dc.contributor.alternativeNameChung, Moon Jae-
dc.contributor.alternativeNameChung, Jae Bock-
dc.contributor.alternativeNameChung, Joo Won-
dc.contributor.alternativeNamePark, Seung Woo-
dc.contributor.alternativeNamePark, Jeong Youp-
dc.contributor.alternativeNamePark, Chan Hyuk-
dc.contributor.alternativeNameBang, Seung Min-
dc.contributor.affiliatedAuthorSong, Si Young-
dc.contributor.affiliatedAuthorChung, Moon Jae-
dc.contributor.affiliatedAuthorChung, Jae Bock-
dc.contributor.affiliatedAuthorChung, Joo Won-
dc.contributor.affiliatedAuthorPark, Seung Woo-
dc.contributor.affiliatedAuthorPark, Jeong Youp-
dc.contributor.affiliatedAuthorPark, Chan Hyuk-
dc.contributor.affiliatedAuthorBang, Seung Min-
dc.citation.volume27-
dc.citation.number8-
dc.citation.startPage1306-
dc.citation.endPage1311-
dc.identifier.bibliographicCitationJOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, Vol.27(8) : 1306-1311, 2012-
dc.identifier.rimsid33552-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers

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