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Early on-treatment predictions of clinical outcomes using alpha-fetoprotein and des-gamma-carboxy prothrombin responses in patients with advanced hepatocellular carcinoma

DC FieldValueLanguage
dc.contributor.author이광훈-
dc.contributor.author이도연-
dc.contributor.author이명하-
dc.contributor.author전재윤-
dc.contributor.author김도영-
dc.contributor.author최은희-
dc.contributor.author김승업-
dc.contributor.author한광협-
dc.contributor.author박준용-
dc.contributor.author성진실-
dc.contributor.author안상훈-
dc.date.accessioned2014-12-19T17:06:54Z-
dc.date.available2014-12-19T17:06:54Z-
dc.date.issued2012-
dc.identifier.issn0815-9319-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/90804-
dc.description.abstractBACKGROUND AND AIM: The clinical utility of alpha-fetoprotein (AFP) and des-γ-carboxy prothrombin (DCP) as a predictor of treatment outcome in patients with advanced hepatocellular carcinoma (HCC) receiving hepatic artery infusional chemotherapy (HAIC) or concurrent chemoradiation therapy (CCRT) has been poorly defined. METHODS: Between January 2003 and December 2007, we enrolled 127 treatment-naïve patients who received HAIC (n = 60) or CCRT (n = 67) as an initial treatment modality. An AFP or DCP response was defined as a reduction of more than 20% from the baseline level. RESULTS: AFP responders showed significantly better overall survival (OS) than non-responders among patients with HAIC (median 17.3 vs 6.4 months, P < 0.001) and with CCRT (median 17.6 vs 8.7 months, P = 0.014). DCP responders in the CCRT group also showed significantly better progression-free survival (PFS) than non-responders (median 9.2 vs 3.1 months, P < 0.001). Multivariate Cox regression analyses showed that AFP response was independently predictive of OS in both groups (P = 0.009 in HAIC and P = 0.008 in CCRT) whereas DCP only predicted PFS in patients with CCRT (P = 0.015). CONCLUSIONS: Early on-treatment AFP response was predictive of OS in treatment-naïve patients with advanced HCC receiving HAIC and CCRT as an initial treatment modality. Furthermore, DCP response was useful for predicting PFS in patients with CCRT.-
dc.description.statementOfResponsibilityopen-
dc.format.extent313~322-
dc.relation.isPartOfJOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdult-
dc.subject.MESHAged-
dc.subject.MESHAntineoplastic Agents/administration & dosage*-
dc.subject.MESHBiomarkers/blood*-
dc.subject.MESHCarcinoma, Hepatocellular/blood*-
dc.subject.MESHCarcinoma, Hepatocellular/mortality-
dc.subject.MESHCarcinoma, Hepatocellular/therapy*-
dc.subject.MESHChemoradiotherapy*-
dc.subject.MESHChi-Square Distribution-
dc.subject.MESHDisease-Free Survival-
dc.subject.MESHFemale-
dc.subject.MESHHepatic Artery-
dc.subject.MESHHumans-
dc.subject.MESHInfusions, Intra-Arterial-
dc.subject.MESHKaplan-Meier Estimate-
dc.subject.MESHLiver Neoplasms/blood*-
dc.subject.MESHLiver Neoplasms/mortality-
dc.subject.MESHLiver Neoplasms/therapy*-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHProportional Hazards Models-
dc.subject.MESHProtein Precursors/blood*-
dc.subject.MESHProthrombin-
dc.subject.MESHRepublic of Korea-
dc.subject.MESHRisk Assessment-
dc.subject.MESHRisk Factors-
dc.subject.MESHTime Factors-
dc.subject.MESHTreatment Outcome-
dc.subject.MESHYoung Adult-
dc.subject.MESHalpha-Fetoproteins/metabolism*-
dc.titleEarly on-treatment predictions of clinical outcomes using alpha-fetoprotein and des-gamma-carboxy prothrombin responses in patients with advanced hepatocellular carcinoma-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Radiation Oncology (방사선종양학)-
dc.contributor.googleauthorMyoung Ha Lee-
dc.contributor.googleauthorSeung Up Kim-
dc.contributor.googleauthorDo Young Kim-
dc.contributor.googleauthorSang Hoon Ahn-
dc.contributor.googleauthorEun Hee Choi-
dc.contributor.googleauthorKwang Hun Lee-
dc.contributor.googleauthorDo Yun Lee-
dc.contributor.googleauthorJinsil Seong-
dc.contributor.googleauthorKwang-Hyub Han-
dc.contributor.googleauthorChae Yoon Chon-
dc.contributor.googleauthorJun Yong Park-
dc.identifier.doi21793906-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA02676-
dc.contributor.localIdA02718-
dc.contributor.localIdA02758-
dc.contributor.localIdA04163-
dc.contributor.localIdA00654-
dc.contributor.localIdA04268-
dc.contributor.localIdA01675-
dc.contributor.localIdA01956-
dc.contributor.localIdA02226-
dc.contributor.localIdA03544-
dc.contributor.localIdA00385-
dc.relation.journalcodeJ01417-
dc.identifier.eissn1440-1746-
dc.identifier.pmid21793906-
dc.identifier.urlhttp://onlinelibrary.wiley.com/doi/10.1111/j.1440-1746.2011.06867.x/abstract-
dc.subject.keywordalpha-fetoprotein-
dc.subject.keywordconcurrent chemoradiation therapy-
dc.subject.keyworddes-gamma-carboxy prothrombin-
dc.subject.keywordhepatic artery hepatocellular carcinoma-
dc.subject.keywordinfusional chemotherapy-
dc.contributor.alternativeNameLee, Kwang Hun-
dc.contributor.alternativeNameLee, Do Yun-
dc.contributor.alternativeNameLee, Myoung Ha-
dc.contributor.alternativeNameChon, Chae Yoon-
dc.contributor.alternativeNameKim, Do Young-
dc.contributor.alternativeNameChoi, Eun Hee-
dc.contributor.alternativeNameKim, Seung Up-
dc.contributor.alternativeNameHan, Kwang Hyup-
dc.contributor.alternativeNamePark, Jun Yong-
dc.contributor.alternativeNameSeong, Jin Sil-
dc.contributor.alternativeNameAhn, Sang Hoon-
dc.contributor.affiliatedAuthorLee, Kwang Hun-
dc.contributor.affiliatedAuthorLee, Do Yun-
dc.contributor.affiliatedAuthorLee, Myoung Ha-
dc.contributor.affiliatedAuthorChoi, Eun Hee-
dc.contributor.affiliatedAuthorKim, Seung Up-
dc.contributor.affiliatedAuthorHan, Kwang Hyup-
dc.contributor.affiliatedAuthorPark, Jun Yong-
dc.contributor.affiliatedAuthorSeong, Jin Sil-
dc.contributor.affiliatedAuthorAhn, Sang Hoon-
dc.contributor.affiliatedAuthorChon, Chae Yoon-
dc.contributor.affiliatedAuthorKim, Do Young-
dc.citation.volume27-
dc.citation.number2-
dc.citation.startPage313-
dc.citation.endPage322-
dc.identifier.bibliographicCitationJOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, Vol.27(2) : 313-322, 2012-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Radiation Oncology (방사선종양학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Biomedical Systems Informatics (의생명시스템정보학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers

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