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Risk of second cancers after the diagnosis of non-melanoma skin cancer in Korean patients

Authors
 Mi Ryung ROH  ;  Hyun Joon SHIN  ;  Soo Hyun LEE  ;  Kee Yang CHUNG 
Citation
 JOURNAL OF DERMATOLOGY, Vol.39(6) : 541-544, 2012 
Journal Title
 JOURNAL OF DERMATOLOGY 
ISSN
 0385-2407 
Issue Date
2012
MeSH
Adult ; Aged ; Asian Continental Ancestry Group ; Case-Control Studies ; Female ; Humans ; Incidence ; Male ; Middle Aged ; Nasopharyngeal Neoplasms/epidemiology ; Neoplasms, Second Primary/epidemiology* ; Republic of Korea/epidemiology ; Risk Factors ; Skin Neoplasms/epidemiology* ; Urinary Bladder Neoplasms/epidemiology
Keywords
cancer risk ; epidemiology ; Korean ; non-melanoma skin cancer ; second primary cancer
Abstract
Individuals with a personal history of non-melanoma skin cancer (NMSC) are known to have an increased risk of subsequent cancers. However, most of the studies regarding this fact were done on Caucasian populations. We investigated whether Korean patients with NMSC have an increased risk of developing second cancers compared to the general Korean population. Five hundred and thirty-two patients diagnosed with NMSC at the Department of Dermatology of Yonsei University Health System from 1999 to 2008 were assessed for development of second cancers. The overall second cancer incidence was increased among patients diagnosed with NMSC compared with the general population in Korea: 37 second cancer total (standardized incidence ratio [SIR] 1.38, 95% confidence interval [CI] 1.10-1.90); 23 second cancers in males (SIR 4.24, 95% CI 2.69-6.36); and 14 second cancers in females (SIR 2.28, 95% CI 1.25-3.83). There were significantly increased incidence ratios for NMSC (eight second cancers [SIR 9.52, 95% CI 4.11-18.77]), bladder cancer (four second cancers [SIR 4.21, 95% CI 1.15-10.78]) and nasopharyngeal cancer (one second cancer [SIR 20.00, 95% CI: 1.51-25.33]). Korean patients diagnosed with NMSC had more second cancers, particularly other skin cancers. This study provides additional evidence that NMSC may be a clinically significant and substantial risk factor for second cancers even in a Korean population, in which the incidence of NMSC is much lower than Caucasians.
Full Text
http://onlinelibrary.wiley.com/doi/10.1111/j.1346-8138.2011.01495.x/abstract
DOI
22380519
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Dermatology (피부과학교실) > 1. Journal Papers
Yonsei Authors
Roh, Mi Ryung(노미령) ORCID logo https://orcid.org/0000-0002-6285-2490
Chung, Kee Yang(정기양) ORCID logo https://orcid.org/0000-0003-3257-0297
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/90759
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