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Diagnostic and prognostic relevance of Cullin1 expression in invasive ductal carcinoma of the breast

Authors
 Kyueng-Whan Min  ;  Dong-Hoon Kim  ;  Sung-Im Do  ;  Jin Hee Sohn  ;  Seoung Wan Chae  ;  Jung-Soo Pyo  ;  Chan Heun Park  ;  Young-Ha Oh  ;  Ki-Seok Jang  ;  Hack-Lyoung Kim  ;  Min Kim 
Citation
 JOURNAL OF CLINICAL PATHOLOGY, Vol.65(10) : 896-901, 2012 
Journal Title
 JOURNAL OF CLINICAL PATHOLOGY 
ISSN
 0021-9746 
Issue Date
2012
MeSH
Adult ; Aged ; Breast Neoplasms/diagnosis* ; Breast Neoplasms/mortality ; Carcinoma, Ductal, Breast/diagnosis* ; Carcinoma, Ductal, Breast/mortality ; Cullin Proteins/metabolism* ; Female ; Humans ; Immunohistochemistry ; Middle Aged ; Prognosis ; Receptor, ErbB-2/metabolism ; Receptors, Estrogen/metabolism ; Receptors, Progesterone/metabolism ; Survival Analysis ; Tissue Array Analysis/methods ; Tumor Suppressor Protein p53/metabolism
Keywords
Adult ; Aged ; Breast Neoplasms/diagnosis* ; Breast Neoplasms/mortality ; Carcinoma, Ductal, Breast/diagnosis* ; Carcinoma, Ductal, Breast/mortality ; Cullin Proteins/metabolism* ; Female ; Humans ; Immunohistochemistry ; Middle Aged ; Prognosis ; Receptor, ErbB-2/metabolism ; Receptors, Estrogen/metabolism ; Receptors, Progesterone/metabolism ; Survival Analysis ; Tissue Array Analysis/methods ; Tumor Suppressor Protein p53/metabolism
Abstract
BACKGROUND: Cullin1 (Cul1) is a matrix degrading enzyme known to be involved in the remodelling of extracellular matrix proteins. This enzyme has recently been reported to play a key role in tumour progression and its presence is associated with poor clinical outcome for several different types of tumours. METHODS: 159 patients diagnosed with invasive ductal carcinoma between 2000 and 2005 were studied. Cul1 expression was analysed by immunohistochemical staining on a tissue microarray. The relationship between Cul1 expression and clinicopathological parameters was evaluated. RESULTS: Tumour expression of Cul1 was correlated with prognostic factors such as high histological grade and p53 expression, and was also linked to negative ER and positive HER2 as therapeutic markers (all p<0.05). There was a significant association between poor overall survival and high Cul1 expression in both univariate and multivariate analyses (all p<0.05). CONCLUSIONS: Cul1 expression was significantly associated with high-grade tumours and poor prognosis, suggesting that it may play a role in breast tumour progression. Cul1 expression may therefore be crucial for the prediction of disease outcome in breast cancer patients.
Full Text
http://jcp.bmj.com/content/65/10/896.long
DOI
22791767
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Ophthalmology (안과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Min(김민) ORCID logo https://orcid.org/0000-0003-1873-6959
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/90702
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