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The geographic origin of Helicobacter pylori influences the association of the homB gene with gastric cancer

Authors
 Jieun Kang  ;  Kathleen R. Jones  ;  Sungil Jang  ;  Cara H. Olsen  ;  Yun-Jung Yoo  ;  D. Scott Merrell  ;  Jeong-Heon Cha 
Citation
 JOURNAL OF CLINICAL MICROBIOLOGY, Vol.50(3) : 1082-1085, 2012 
Journal Title
 JOURNAL OF CLINICAL MICROBIOLOGY 
ISSN
 0095-1137 
Issue Date
2012
MeSH
Adult ; Aged ; Antigens, Bacterial/genetics ; Asia ; Bacterial Outer Membrane Proteins/genetics* ; Bacterial Proteins/genetics ; Female ; Gene Dosage ; Helicobacter pylori/genetics ; Helicobacter pylori/isolation & purification* ; Helicobacter pylori/pathogenicity* ; Humans ; Male ; Middle Aged ; Stomach Neoplasms/microbiology* ; Virulence Factors/genetics*
Keywords
Adult ; Aged ; Antigens, Bacterial/genetics ; Asia ; Bacterial Outer Membrane Proteins/genetics* ; Bacterial Proteins/genetics ; Female ; Gene Dosage ; Helicobacter pylori/genetics ; Helicobacter pylori/isolation & purification* ; Helicobacter pylori/pathogenicity* ; Humans ; Male ; Middle Aged ; Stomach Neoplasms/microbiology* ; Virulence Factors/genetics*
Abstract
We found that South Korean Helicobacter pylori isolates predominantly carry homB at locus B and that there is no association between the homB allele and the cagA allele or the development of gastric cancer within this population. Uniquely, several East Asian strains carried multiple copies of the hom genes.
Files in This Item:
T201200215.pdf Download
DOI
22205793
Appears in Collections:
2. College of Dentistry (치과대학) > Dept. of Oral Biology (구강생물학교실) > 1. Journal Papers
Yonsei Authors
Kang, Ji Eun(강지은)
Yoo, Yun Jung(유윤정) ORCID logo https://orcid.org/0000-0002-0045-9597
Jang, Sungil(장성일) ORCID logo https://orcid.org/0000-0001-6144-6899
Cha, Jung Heon(차정헌) ORCID logo https://orcid.org/0000-0002-9385-2653
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/90692
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