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Variants of the adiponectin and adiponectin receptor-1 genes and posttransplantation diabetes mellitus in renal allograft recipients

Authors
 Eun Seok Kang  ;  Faidon Magkos  ;  Beom Seok Kim  ;  Rihong Zhai  ;  Li Su  ;  Yu Seun Kim  ;  David C. Christiani  ;  Hyun Chul Lee  ;  Christos S. Mantzoros 
Citation
 JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, Vol.97(1) : 129-135, 2012 
Journal Title
 JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM 
ISSN
 0021-972X 
Issue Date
2012
MeSH
Adiponectin/genetics ; Adult ; Diabetes Mellitus/etiology* ; Diabetes Mellitus/genetics ; Female ; Follow-Up Studies ; Gene Frequency ; Genetic Predisposition to Disease ; Genotype ; Humans ; Kidney Transplantation/adverse effects* ; Male ; Middle Aged ; Polymorphism, Single Nucleotide*/physiology ; Receptors, Adiponectin/genetics* ; Sex Factors ; Transplantation, Homologous
Keywords
Adiponectin/genetics ; Adult ; Diabetes Mellitus/etiology* ; Diabetes Mellitus/genetics ; Female ; Follow-Up Studies ; Gene Frequency ; Genetic Predisposition to Disease ; Genotype ; Humans ; Kidney Transplantation/adverse effects* ; Male ; Middle Aged ; Polymorphism, Single Nucleotide*/physiology ; Receptors, Adiponectin/genetics* ; Sex Factors ; Transplantation, Homologous
Abstract
CONTEXT: Posttransplantation diabetes mellitus (PTDM) is a major metabolic complication in renal transplant recipients. Adiponectin (ADIPOQ) and adiponectin receptor-1 (ADIPOR1) gene polymorphisms have been associated with type 2 diabetes. However, it is unknown whether these polymorphisms are also risk factors for PTDM. OBJECTIVE: We investigated the association between PTDM and single-nucleotide polymorphisms of ADIPOQ and ADIPOR1 in a cohort of renal allograft recipients. DESIGN, SETTING, AND PARTICIPANTS: Five hundred seventy-five patients (367 men and 208 women) who received kidney transplants between 1989 and 2007, without a history of diabetes and with a pretransplant fasting glucose concentration less than 5.5 mmol/liter. Patients were followed up for a median 10 yr. Genotypes included single-nucleotide polymorphisms of the following: ADIPOQ rs266729, rs822395, rs822396, rs2241766, and rs1501299 and ADIPOR1 rs2232853, rs12733285, and rs1342387. RESULTS: TT-homozygotes in ADIPOQ rs1501299 [hazard ratio (HR) = 1.70, P = 0.032] had greater risk of PTDM after adjusting for age, sex, amount of weight gain, and type of immunosuppressant. There was a significant interaction between sex and ADIPOQ rs1501299 genotype (P = 0.037). In men, but not in women, TT-homozygotes in ADIPOQ rs1501299 were more likely to develop PTDM than the wild GG-homozygotes (HR = 2.50, P = 0.002), whereas GT-heterozygotes had nonsignificantly elevated risk (HR = 1.41, P = 0.128). CONCLUSION: Genetic variation in ADIPOQ rs1501299 is associated with PTDM in a sex-specific manner.
Files in This Item:
T201200070.pdf Download
DOI
22049178
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Kang, Eun Seok(강은석) ORCID logo https://orcid.org/0000-0002-0364-4675
Kim, Beom Seok(김범석) ORCID logo https://orcid.org/0000-0002-5732-2583
Kim, Yu Seun(김유선) ORCID logo https://orcid.org/0000-0002-5105-1567
Lee, Hyun Chul(이현철)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/90679
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