Cited 22 times in
Variants of the adiponectin and adiponectin receptor-1 genes and posttransplantation diabetes mellitus in renal allograft recipients
DC Field | Value | Language |
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dc.contributor.author | 김유선 | - |
dc.contributor.author | 이현철 | - |
dc.contributor.author | 강은석 | - |
dc.contributor.author | 김범석 | - |
dc.date.accessioned | 2014-12-19T17:02:54Z | - |
dc.date.available | 2014-12-19T17:02:54Z | - |
dc.date.issued | 2012 | - |
dc.identifier.issn | 0021-972X | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/90679 | - |
dc.description.abstract | CONTEXT: Posttransplantation diabetes mellitus (PTDM) is a major metabolic complication in renal transplant recipients. Adiponectin (ADIPOQ) and adiponectin receptor-1 (ADIPOR1) gene polymorphisms have been associated with type 2 diabetes. However, it is unknown whether these polymorphisms are also risk factors for PTDM. OBJECTIVE: We investigated the association between PTDM and single-nucleotide polymorphisms of ADIPOQ and ADIPOR1 in a cohort of renal allograft recipients. DESIGN, SETTING, AND PARTICIPANTS: Five hundred seventy-five patients (367 men and 208 women) who received kidney transplants between 1989 and 2007, without a history of diabetes and with a pretransplant fasting glucose concentration less than 5.5 mmol/liter. Patients were followed up for a median 10 yr. Genotypes included single-nucleotide polymorphisms of the following: ADIPOQ rs266729, rs822395, rs822396, rs2241766, and rs1501299 and ADIPOR1 rs2232853, rs12733285, and rs1342387. RESULTS: TT-homozygotes in ADIPOQ rs1501299 [hazard ratio (HR) = 1.70, P = 0.032] had greater risk of PTDM after adjusting for age, sex, amount of weight gain, and type of immunosuppressant. There was a significant interaction between sex and ADIPOQ rs1501299 genotype (P = 0.037). In men, but not in women, TT-homozygotes in ADIPOQ rs1501299 were more likely to develop PTDM than the wild GG-homozygotes (HR = 2.50, P = 0.002), whereas GT-heterozygotes had nonsignificantly elevated risk (HR = 1.41, P = 0.128). CONCLUSION: Genetic variation in ADIPOQ rs1501299 is associated with PTDM in a sex-specific manner. | - |
dc.description.statementOfResponsibility | open | - |
dc.format | application/pdf | - |
dc.relation.isPartOf | JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adiponectin/genetics | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Diabetes Mellitus/etiology* | - |
dc.subject.MESH | Diabetes Mellitus/genetics | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Follow-Up Studies | - |
dc.subject.MESH | Gene Frequency | - |
dc.subject.MESH | Genetic Predisposition to Disease | - |
dc.subject.MESH | Genotype | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Kidney Transplantation/adverse effects* | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Polymorphism, Single Nucleotide*/physiology | - |
dc.subject.MESH | Receptors, Adiponectin/genetics* | - |
dc.subject.MESH | Sex Factors | - |
dc.subject.MESH | Transplantation, Homologous | - |
dc.title | Variants of the adiponectin and adiponectin receptor-1 genes and posttransplantation diabetes mellitus in renal allograft recipients | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Surgery (외과학) | - |
dc.contributor.googleauthor | Eun Seok Kang | - |
dc.contributor.googleauthor | Faidon Magkos | - |
dc.contributor.googleauthor | Beom Seok Kim | - |
dc.contributor.googleauthor | Rihong Zhai | - |
dc.contributor.googleauthor | Li Su | - |
dc.contributor.googleauthor | Yu Seun Kim | - |
dc.contributor.googleauthor | David C. Christiani | - |
dc.contributor.googleauthor | Hyun Chul Lee | - |
dc.contributor.googleauthor | Christos S. Mantzoros | - |
dc.identifier.doi | 10.1210/jc.2011-1796 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A00785 | - |
dc.contributor.localId | A03301 | - |
dc.contributor.localId | A00068 | - |
dc.contributor.localId | A00488 | - |
dc.relation.journalcode | J01318 | - |
dc.identifier.eissn | 1945-7197 | - |
dc.identifier.pmid | 22049178 | - |
dc.contributor.alternativeName | Kim, Yu Seun | - |
dc.contributor.alternativeName | Lee, Hyun Chul | - |
dc.contributor.alternativeName | Kang, Eun Seok | - |
dc.contributor.alternativeName | Kim, Beom Seok | - |
dc.contributor.affiliatedAuthor | Kim, Yu Seun | - |
dc.contributor.affiliatedAuthor | Lee, Hyun Chul | - |
dc.contributor.affiliatedAuthor | Kang, Eun Seok | - |
dc.contributor.affiliatedAuthor | Kim, Beom Seok | - |
dc.citation.volume | 97 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 129 | - |
dc.citation.endPage | 135 | - |
dc.identifier.bibliographicCitation | JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, Vol.97(1) : 129-135, 2012 | - |
dc.identifier.rimsid | 33461 | - |
dc.type.rims | ART | - |
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