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Age-related bone mineral density patterns in Koreans (KNHANES IV)

 Eun Young Lee  ;  Daham Kim  ;  Kyoung Min Kim  ;  Kwang Joon Kim  ;  Han Seok Choi  ;  Yumie Rhee  ;  Sung-Kil Lim 
 Journal of Clinical Endocrinology & Metabolism, Vol.97(9) : 3310-3318, 2012 
Journal Title
 Journal of Clinical Endocrinology & Metabolism 
Issue Date
CONTEXT: Bone loss is considered to begin with menopause in women and later in life in men; however, several recent studies have reported that bone loss began in young adults. There are still discordant results concerning age-related changes in bone mineral density (BMD), especially in nonvertebral bone. OBJECTIVE: The objective of the study was to investigate the age-related changes in BMD in Korean youth. DESIGN AND SETTING: This was a population-based, cross-sectional study from the Fourth Korea National Health and Nutrition Examination Surveys. PARTICIPANTS: A total 10,575 Korean (4,731 males and 5,844 females) aged 10-80 yr were included. MAIN OUTCOME MEASURES: BMD at the spine and hip was measured using dual X-ray absorptiometry. RESULTS: Age-related bone loss at the femoral neck in males occurred continuously with temporary acceleration phase after achieving peak bone mass (PBM). In contrast, age-related bone loss at total hip in both sexes and femoral neck in females showed three obvious phases: acceleration, consolidation, and then the second acceleration phase after reaching PBM. Interestingly, this pattern of bone loss was more significant in the total hip and thus showed the acceleration phase until the late 20s and the consolidation phase until the late 40s. Early accelerated loss of BMD was not observed at the lumbar spine in each sex. Although body mass index and body fat percentage were more related with BMD than other clinical parameters, they could not explain the early accelerated loss of BMD at the femur. CONCLUSIONS: There was an accelerated bone loss at the femur in both sexes during early adulthood and more than 60% of the bone loss before age 50 yr occurred during this period.
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1. College of Medicine (의과대학) > Dept. of Biochemistry and Molecular Biology (생화학-분자생물학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
김경민(Kim, Kyung Min)
김광준(Kim, Kwang Joon) ORCID logo https://orcid.org/0000-0002-5554-8255
김다함(Kim, Daham) ORCID logo https://orcid.org/0000-0003-1871-686X
이유미(Rhee, Yumie) ORCID logo https://orcid.org/0000-0003-4227-5638
이은영(Lee, Eun Young)
임승길(Lim, Sung Kil)
최한석(Choi, Han Seok)
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