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Effect of atorvastatin monotherapy and low-dose atorvastatin/ezetimibe combination on fasting and postprandial triglycerides in combined hyperlipedemia

Authors
 Sang-Hak Lee  ;  Sungha Park  ;  Seok-Min Kang  ;  Yangsoo Jang  ;  Namsik Chung  ;  Donghoon Choi 
Citation
 JOURNAL OF CARDIOVASCULAR PHARMACOLOGY AND THERAPEUTICS, Vol.17(1) : 65-71, 2012 
Journal Title
 JOURNAL OF CARDIOVASCULAR PHARMACOLOGY AND THERAPEUTICS 
ISSN
 1074-2484 
Issue Date
2012
MeSH
Adult ; Aged ; Atorvastatin Calcium ; Azetidines/administration & dosage* ; Drug Therapy, Combination ; Ezetimibe ; Fasting/blood* ; Female ; Heptanoic Acids/administration & dosage* ; Humans ; Hyperlipidemias/blood* ; Hyperlipidemias/drug therapy ; Male ; Middle Aged ; Postprandial Period/drug effects ; Postprandial Period/physiology* ; Pyrroles/administration & dosage* ; Treatment Outcome ; Triglycerides/blood* ; Young Adult
Keywords
atorvastatin ; ezetimibe ; postprandial period ; hypertriglyceridemia
Abstract
Postprandial triglyceride (TG) levels are easy to measure and are associated with future cardiovascular risk. The aim of this study was to compare the effects of statin monotherapy and low-dose statin/ezetimibe on lipid parameters including fasting and postprandial TG. After a 4-week dietary run-in period, 78 patients with combined hyperlipidemia were randomized into 1 of 2 treatment groups for 8 weeks: atorvastatin 20 mg or atorvastatin/ezetimibe 5 mg/5 mg. An oral fat load test was performed before and after the drug-treatment period. The low-dose combination had a tendency to decrease fasting TG more than atorvastatin monotherapy. The combination regimen showed a greater reduction in postprandial TG (-13% ± 42% and -34% ± 30%, in the atorvastatin and combination groups, respectively, P = .03) and total cholesterol (TC; P = .03). The changes in low-density lipoprotein-cholesterol (LDL-C) and high-density lipoprotein-cholesterol (HDL-C) were not different between the 2 groups. The reduction in apo B/A1 was greater in the combination group (-32% ± 19% and -42% ± 13%, in the atorvastatin and combination groups, respectively, P = .02). In conclusion, these results demonstrated a potential beneficial effect of low-dose atorvastatin/ezetimibe combination treatment on postprandial TG control after comparable LDL-C lowering in patients with combined hyperlipidemia.
Full Text
http://cpt.sagepub.com/content/17/1/65.abstract
DOI
21386036
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Kang, Seok Min(강석민) ORCID logo https://orcid.org/0000-0001-9856-9227
Park, Sung Ha(박성하) ORCID logo https://orcid.org/0000-0001-5362-478X
Lee, Sang Hak(이상학) ORCID logo https://orcid.org/0000-0002-4535-3745
Jang, Yang Soo(장양수) ORCID logo https://orcid.org/0000-0002-2169-3112
Chung, Nam Sik(정남식)
Choi, Dong Hoon(최동훈) ORCID logo https://orcid.org/0000-0002-2009-9760
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/90657
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