Cited 21 times in
Mycobacterium paratuberculosis CobT activates dendritic cells via engagement of Toll-like receptor 4 resulting in Th1 cell expansion
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 이기훈 | - |
dc.contributor.author | 조상래 | - |
dc.contributor.author | 김종석 | - |
dc.contributor.author | 변의홍 | - |
dc.contributor.author | 신성재 | - |
dc.date.accessioned | 2014-12-19T17:01:11Z | - |
dc.date.available | 2014-12-19T17:01:11Z | - |
dc.date.issued | 2012 | - |
dc.identifier.issn | 0021-9258 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/90626 | - |
dc.description.abstract | Mycobacterium avium subsp. paratuberculosis (MAP) is the causative agent of Johne disease in animals and MAP involvement in human Crohn disease has been recently emphasized. Evidence from M. tuberculosis studies suggests mycobacterial proteins activate dendritic cells (DCs) via Toll-like receptor (TLR) 4, eventually determining the fate of immune responses. Here, we investigated whether MAP CobT contributes to the development of T cell immunity through the activation of DCs. MAP CobT recognizes TLR4, and induces DC maturation and activation via the MyD88 and TRIF signaling cascades, which are followed by MAP kinases and NF-κB. We further found that MAP CobT-treated DCs activated naive T cells, effectively polarized CD4(+) and CD8(+) T cells to secrete IFN-γ and IL-2, but not IL-4 and IL-10, and induced T cell proliferation. These data indicate that MAP CobT contributes to T helper (Th) 1 polarization of the immune response. MAP CobT-treated DCs specifically induced the expansion of CD4(+)/CD8(+)CD44(high)CD62L(low) memory T cells in the mesenteric lymph node of MAP-infected mice in a TLR4-dependent manner. Our results indicate that MAP CobT is a novel DC maturation-inducing antigen that drives Th1 polarized-naive/memory T cell expansion in a TLR4-dependent cascade, suggesting that MAP CobT potentially links innate and adaptive immunity against MAP. | - |
dc.description.statementOfResponsibility | open | - |
dc.relation.isPartOf | JOURNAL OF BIOLOGICAL CHEMISTRY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Bacterial Proteins/metabolism | - |
dc.subject.MESH | Dendritic Cells/cytology | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Immune System | - |
dc.subject.MESH | Immunologic Memory | - |
dc.subject.MESH | Interferon-gamma/metabolism | - |
dc.subject.MESH | Mice | - |
dc.subject.MESH | Mice, Inbred BALB C | - |
dc.subject.MESH | Mice, Inbred C57BL | - |
dc.subject.MESH | Mice, Knockout | - |
dc.subject.MESH | Models, Biological | - |
dc.subject.MESH | Multienzyme Complexes/genetics* | - |
dc.subject.MESH | Multienzyme Complexes/physiology | - |
dc.subject.MESH | Mycobacterium avium subsp. paratuberculosis/metabolism* | - |
dc.subject.MESH | Nucleotidyltransferases/genetics* | - |
dc.subject.MESH | Nucleotidyltransferases/physiology | - |
dc.subject.MESH | Pentosyltransferases/genetics* | - |
dc.subject.MESH | Pentosyltransferases/physiology | - |
dc.subject.MESH | Recombinant Proteins/chemistry | - |
dc.subject.MESH | T-Lymphocytes/immunology | - |
dc.subject.MESH | Th1 Cells/cytology | - |
dc.subject.MESH | Toll-Like Receptor 4/metabolism | - |
dc.title | Mycobacterium paratuberculosis CobT activates dendritic cells via engagement of Toll-like receptor 4 resulting in Th1 cell expansion | - |
dc.type | Article | - |
dc.contributor.college | Researcher Institutes (부설 연구소) | - |
dc.contributor.department | Institute for Immunology and Immunological Disease (면역질환연구소) | - |
dc.contributor.googleauthor | Eui-Hong Byun | - |
dc.contributor.googleauthor | Woo Sik Kim | - |
dc.contributor.googleauthor | Jong-Seok Kim | - |
dc.contributor.googleauthor | Choul-Jae Won | - |
dc.contributor.googleauthor | Han-Gyu Choi | - |
dc.contributor.googleauthor | Hwa-Jung Kim | - |
dc.contributor.googleauthor | Sang-Nae Cho | - |
dc.contributor.googleauthor | Keehoon Lee | - |
dc.contributor.googleauthor | Tiejun Zhang | - |
dc.contributor.googleauthor | Gang Min Hur | - |
dc.contributor.googleauthor | Sung Jae Shin | - |
dc.identifier.doi | 10.1074/jbc.M112.391060 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A02699 | - |
dc.contributor.localId | A03824 | - |
dc.contributor.localId | A01855 | - |
dc.contributor.localId | A00920 | - |
dc.contributor.localId | A02114 | - |
dc.relation.journalcode | J01258 | - |
dc.identifier.eissn | 1083-351X | - |
dc.identifier.pmid | 23019321 | - |
dc.identifier.url | http://www.jbc.org/content/287/46/38609.long | - |
dc.subject.keyword | Dendritic Cells | - |
dc.subject.keyword | Immunology | - |
dc.subject.keyword | Mycobacteria | - |
dc.subject.keyword | T Cell | - |
dc.subject.keyword | Toll-like Receptors (TLR) | - |
dc.subject.keyword | Memory T Cell | - |
dc.subject.keyword | Mycobacterium avium subsp. paratuberculosis | - |
dc.subject.keyword | Th1 Polarization | - |
dc.subject.keyword | Toll-like Receptor 4 | - |
dc.contributor.alternativeName | Lee, Kee Hoon | - |
dc.contributor.alternativeName | Cho, Sang Nae | - |
dc.contributor.alternativeName | Kim, Jong Seok | - |
dc.contributor.alternativeName | Byun, Eui Hong | - |
dc.contributor.alternativeName | Shin, Sung Jae | - |
dc.contributor.affiliatedAuthor | Lee, Kee Hoon | - |
dc.contributor.affiliatedAuthor | Cho, Sang Nae | - |
dc.contributor.affiliatedAuthor | Byun, Eui Hong | - |
dc.contributor.affiliatedAuthor | Kim, Jong Seok | - |
dc.contributor.affiliatedAuthor | Shin, Sung Jae | - |
dc.citation.volume | 287 | - |
dc.citation.number | 46 | - |
dc.citation.startPage | 38609 | - |
dc.citation.endPage | 38624 | - |
dc.identifier.bibliographicCitation | JOURNAL OF BIOLOGICAL CHEMISTRY, Vol.287(46) : 38609-38624, 2012 | - |
dc.identifier.rimsid | 32883 | - |
dc.type.rims | ART | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.