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Pre-transplant risk factors for tuberculosis after kidney transplant in an intermediate burden area.

 Jung, J. Y. ; Joo, D. J. ; Kang, Y. A. ; Chang, J. ; Kim, S. K. ; Kim, S. I. ; Kim, M. S. ; Kim, Y. S. ; Park, M. S. ; Lee, C-H. 
 International Journal of Tuberculosis and Lung Disease, Vol.16(2) : 248~254, 2012 
Journal Title
 International Journal of Tuberculosis and Lung Disease 
Issue Date
OBJECTIVE: To examine pre-transplant risk factors for the development of post-kidney transplant tuberculosis (TB) in an intermediate TB burden country, as this is important for early detection and prophylaxis to prevent post-transplant TB. DESIGN: A retrospective, longitudinal cohort study of 1097 kidney transplant patients was performed at the Severance Hospital, Seoul, South Korea, between January 2000 and March 2010. The standardised incidence ratio (SIR) of post-transplant TB compared to the general population was calculated and pre-transplant risk factors were analysed. RESULTS: Among the 1097 kidney transplant patients, 2.1% (23/1097) developed post-transplant TB, with an incidence of 445.2 cases per 100,000 patients per year. The SIR of TB in kidney transplant patients compared with the general population was 4.26 (95%CI 2.6-6.45). A positive tuberculin skin test (TST; RR 3.54, 95%CI 1.13-11.11, P = 0.03) and previously healed TB on chest radiograph (CXR; RR 8.71, 95%CI 1.00-75.84, P = 0.05) were significant pre-transplant risk factors for post-transplant TB on multivariate analysis. CONCLUSION: The incidence of TB in kidney transplant patients was higher than in the general population. Positive TST results and previously healed TB lesions visible on pre-transplant CXR were significant pre-transplant risk factors for post-kidney transplant TB.
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1. 연구논문 > 1. College of Medicine > Dept. of Internal Medicine
1. 연구논문 > 1. College of Medicine > Dept. of Surgery
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