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Pre-transplant risk factors for tuberculosis after kidney transplant in an intermediate burden area.

Authors
 Jung, J. Y.  ;  Joo, D. J.  ;  Lee, C-H.  ;  Park, M. S.  ;  Kim, Y. S.  ;  Kim, M. S.  ;  Kim, S. I.  ;  Kim, Y. S.  ;  Kim, S. K.  ;  Chang, J.  ;  Kang, Y. A. 
Citation
 INTERNATIONAL JOURNAL OF TUBERCULOSIS AND LUNG DISEASE, Vol.16(2) : 248-254, 2012 
Journal Title
 INTERNATIONAL JOURNAL OF TUBERCULOSIS AND LUNG DISEASE 
ISSN
 1027-3719 
Issue Date
2012
MeSH
Adolescent ; Adult ; Aged ; Female ; Follow-Up Studies ; Humans ; Incidence ; Kidney Transplantation* ; Male ; Middle Aged ; Postoperative Period ; Preoperative Period ; Republic of Korea/epidemiology ; Retrospective Studies ; Risk Assessment/methods* ; Risk Factors ; Tuberculin Test ; Tuberculosis/diagnosis ; Tuberculosis/epidemiology* ; Young Adult
Keywords
kidney transplantation ; risk factors ; tuberculosis
Abstract
OBJECTIVE: To examine pre-transplant risk factors for the development of post-kidney transplant tuberculosis (TB) in an intermediate TB burden country, as this is important for early detection and prophylaxis to prevent post-transplant TB. DESIGN: A retrospective, longitudinal cohort study of 1097 kidney transplant patients was performed at the Severance Hospital, Seoul, South Korea, between January 2000 and March 2010. The standardised incidence ratio (SIR) of post-transplant TB compared to the general population was calculated and pre-transplant risk factors were analysed. RESULTS: Among the 1097 kidney transplant patients, 2.1% (23/1097) developed post-transplant TB, with an incidence of 445.2 cases per 100,000 patients per year. The SIR of TB in kidney transplant patients compared with the general population was 4.26 (95%CI 2.6-6.45). A positive tuberculin skin test (TST; RR 3.54, 95%CI 1.13-11.11, P = 0.03) and previously healed TB on chest radiograph (CXR; RR 8.71, 95%CI 1.00-75.84, P = 0.05) were significant pre-transplant risk factors for post-transplant TB on multivariate analysis. CONCLUSION: The incidence of TB in kidney transplant patients was higher than in the general population. Positive TST results and previously healed TB lesions visible on pre-transplant CXR were significant pre-transplant risk factors for post-kidney transplant TB.
Full Text
http://dx.doi.org/10.5588/ijtld.11.0259
DOI
22236928
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
Yonsei Authors
Kang, Young Ae(강영애) ORCID logo https://orcid.org/0000-0002-7783-5271
Kim, Myoung Soo(김명수) ORCID logo https://orcid.org/0000-0002-8975-8381
Kim, Se Kyu(김세규)
Kim, Soon Il(김순일) ORCID logo https://orcid.org/0000-0002-0783-7538
Kim, Young Sam(김영삼) ORCID logo https://orcid.org/0000-0001-9656-8482
Kim, Yu Seun(김유선) ORCID logo https://orcid.org/0000-0002-5105-1567
Park, Moo Suk(박무석) ORCID logo https://orcid.org/0000-0003-0820-7615
Chang, Joon(장준) ORCID logo https://orcid.org/0000-0003-4542-6841
Jung, Ji Ye(정지예) ORCID logo https://orcid.org/0000-0003-1589-4142
Joo, Dong Jin(주동진) ORCID logo https://orcid.org/0000-0001-8405-1531
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/90551
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