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Pulmonary hypertension associated with rheumatic diseases: baseline characteristics from the Korean registry.

Authors
 Chan Hong Jeon  ;  Ji-Young Chai  ;  Young-Il Seo  ;  Jae-Bum Jun  ;  Eun-Mi Koh  ;  Soo-Kon Lee 
Citation
 INTERNATIONAL JOURNAL OF RHEUMATIC DISEASES, Vol.15(5) : 80-89, 2012 
Journal Title
 INTERNATIONAL JOURNAL OF RHEUMATIC DISEASES 
ISSN
 1756-1841 
Issue Date
2012
MeSH
Adult ; Aged ; Arthritis, Rheumatoid/blood ; Arthritis, Rheumatoid/epidemiology ; Arthritis, Rheumatoid/physiopathology ; Data Collection ; Female ; Hemodynamics/physiology ; Humans ; Hypertension, Pulmonary/blood* ; Hypertension, Pulmonary/epidemiology ; Hypertension, Pulmonary/physiopathology* ; Lupus Erythematosus, Systemic/blood ; Lupus Erythematosus, Systemic/epidemiology ; Lupus Erythematosus, Systemic/physiopathology ; Male ; Middle Aged ; Mixed Connective Tissue Disease/blood ; Mixed Connective Tissue Disease/epidemiology ; Mixed Connective Tissue Disease/physiopathology ; Natriuretic Peptide, Brain/blood ; Peptide Fragments/blood ; Pulmonary Diffusing Capacity/physiology ; Registries* ; Republic of Korea/epidemiology ; Retrospective Studies ; Rheumatic Diseases/complications* ; Scleroderma, Systemic/blood ; Scleroderma, Systemic/epidemiology ; Scleroderma, Systemic/physiopathology
Keywords
Adult ; Aged ; Arthritis, Rheumatoid/blood ; Arthritis, Rheumatoid/epidemiology ; Arthritis, Rheumatoid/physiopathology ; Data Collection ; Female ; Hemodynamics/physiology ; Humans ; Hypertension, Pulmonary/blood* ; Hypertension, Pulmonary/epidemiology ; Hypertension, Pulmonary/physiopathology* ; Lupus Erythematosus, Systemic/blood ; Lupus Erythematosus, Systemic/epidemiology ; Lupus Erythematosus, Systemic/physiopathology ; Male ; Middle Aged ; Mixed Connective Tissue Disease/blood ; Mixed Connective Tissue Disease/epidemiology ; Mixed Connective Tissue Disease/physiopathology ; Natriuretic Peptide, Brain/blood ; Peptide Fragments/blood ; Pulmonary Diffusing Capacity/physiology ; Registries* ; Republic of Korea/epidemiology ; Retrospective Studies ; Rheumatic Diseases/complications* ; Scleroderma, Systemic/blood ; Scleroderma, Systemic/epidemiology ; Scleroderma, Systemic/physiopathology
Abstract
OBJECTIVES: The REgistry of Pulmonary Hypertension Associated with Rheumatic Disease (REOPARD) was established in Korea. The baseline data are described from the second year of the registry's operation. METHODS: Patients with a connective tissue disease (CTD) who met the modified definition of the WHO group I pulmonary arterial hypertension (PAH) were enrolled. PAH was defined as a systolic pulmonary arterial pressure> 40 mmHg by echocardiography or mean pulmonary arterial pressure> 25 mmHg by right heart catheterization. Hemodynamic parameters and clinical data such as demographics, functional class, underlying disease, organ involvement, laboratory tests and current treatment were recorded. RESULTS: A total of 321 patients were enrolled during the 2-year study period from 2008 to 2010. The mean age of the patients at registration was 51.9 years and 87.5% were female. Most patients were diagnosed by echocardiography and only 24 patients (7.5%) underwent cardiac catheterization. Exertional dyspnea was present in 63.6% of patients and 31.8% were New York Heart Association class III or IV. Among the patients, systemic lupus erythematosus accounted for 35.3%, systemic sclerosis 28.3%, rheumatoid arthritis 7.8%, overlap syndrome 9.0%, and mixed connective tissue disease 5.9%. There were no significant differences in hemodynamics, functional class, diffusing capacity and N-terminal pro-brain natriuretic peptide levels between the disease subgroups. Treatments consisted of calcium antagonists (57.0%), endothelin antagonists (32.7%), prostanoids (27.1%), phosphodiesterase-5 inhibitors (14.3%) and combinations (37.4%). CONCLUSION: Compared with previous studies, the results showed some differences: underlying diseases, functional status and treatments. This may be due to differences in ethnic background and diagnostic methods of our study.
Full Text
http://onlinelibrary.wiley.com/doi/10.1111/j.1756-185X.2012.01815.x/abstract
DOI
23083052
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Lee, Soo Kon(이수곤)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/90546
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