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Pulmonary hypertension associated with rheumatic diseases: baseline characteristics from the Korean registry.
DC Field | Value | Language |
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dc.contributor.author | 이수곤 | - |
dc.date.accessioned | 2014-12-19T16:58:34Z | - |
dc.date.available | 2014-12-19T16:58:34Z | - |
dc.date.issued | 2012 | - |
dc.identifier.issn | 1756-1841 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/90546 | - |
dc.description.abstract | OBJECTIVES: The REgistry of Pulmonary Hypertension Associated with Rheumatic Disease (REOPARD) was established in Korea. The baseline data are described from the second year of the registry's operation. METHODS: Patients with a connective tissue disease (CTD) who met the modified definition of the WHO group I pulmonary arterial hypertension (PAH) were enrolled. PAH was defined as a systolic pulmonary arterial pressure> 40 mmHg by echocardiography or mean pulmonary arterial pressure> 25 mmHg by right heart catheterization. Hemodynamic parameters and clinical data such as demographics, functional class, underlying disease, organ involvement, laboratory tests and current treatment were recorded. RESULTS: A total of 321 patients were enrolled during the 2-year study period from 2008 to 2010. The mean age of the patients at registration was 51.9 years and 87.5% were female. Most patients were diagnosed by echocardiography and only 24 patients (7.5%) underwent cardiac catheterization. Exertional dyspnea was present in 63.6% of patients and 31.8% were New York Heart Association class III or IV. Among the patients, systemic lupus erythematosus accounted for 35.3%, systemic sclerosis 28.3%, rheumatoid arthritis 7.8%, overlap syndrome 9.0%, and mixed connective tissue disease 5.9%. There were no significant differences in hemodynamics, functional class, diffusing capacity and N-terminal pro-brain natriuretic peptide levels between the disease subgroups. Treatments consisted of calcium antagonists (57.0%), endothelin antagonists (32.7%), prostanoids (27.1%), phosphodiesterase-5 inhibitors (14.3%) and combinations (37.4%). CONCLUSION: Compared with previous studies, the results showed some differences: underlying diseases, functional status and treatments. This may be due to differences in ethnic background and diagnostic methods of our study. | - |
dc.description.statementOfResponsibility | open | - |
dc.relation.isPartOf | INTERNATIONAL JOURNAL OF RHEUMATIC DISEASES | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Arthritis, Rheumatoid/blood | - |
dc.subject.MESH | Arthritis, Rheumatoid/epidemiology | - |
dc.subject.MESH | Arthritis, Rheumatoid/physiopathology | - |
dc.subject.MESH | Data Collection | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Hemodynamics/physiology | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Hypertension, Pulmonary/blood* | - |
dc.subject.MESH | Hypertension, Pulmonary/epidemiology | - |
dc.subject.MESH | Hypertension, Pulmonary/physiopathology* | - |
dc.subject.MESH | Lupus Erythematosus, Systemic/blood | - |
dc.subject.MESH | Lupus Erythematosus, Systemic/epidemiology | - |
dc.subject.MESH | Lupus Erythematosus, Systemic/physiopathology | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Mixed Connective Tissue Disease/blood | - |
dc.subject.MESH | Mixed Connective Tissue Disease/epidemiology | - |
dc.subject.MESH | Mixed Connective Tissue Disease/physiopathology | - |
dc.subject.MESH | Natriuretic Peptide, Brain/blood | - |
dc.subject.MESH | Peptide Fragments/blood | - |
dc.subject.MESH | Pulmonary Diffusing Capacity/physiology | - |
dc.subject.MESH | Registries* | - |
dc.subject.MESH | Republic of Korea/epidemiology | - |
dc.subject.MESH | Retrospective Studies | - |
dc.subject.MESH | Rheumatic Diseases/complications* | - |
dc.subject.MESH | Scleroderma, Systemic/blood | - |
dc.subject.MESH | Scleroderma, Systemic/epidemiology | - |
dc.subject.MESH | Scleroderma, Systemic/physiopathology | - |
dc.title | Pulmonary hypertension associated with rheumatic diseases: baseline characteristics from the Korean registry. | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학) | - |
dc.contributor.googleauthor | Chan Hong Jeon | - |
dc.contributor.googleauthor | Ji-Young Chai | - |
dc.contributor.googleauthor | Young-Il Seo | - |
dc.contributor.googleauthor | Jae-Bum Jun | - |
dc.contributor.googleauthor | Eun-Mi Koh | - |
dc.contributor.googleauthor | Soo-Kon Lee | - |
dc.identifier.doi | 23083052 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A02889 | - |
dc.relation.journalcode | J01158 | - |
dc.identifier.eissn | 1756-185X | - |
dc.identifier.pmid | 23083052 | - |
dc.identifier.url | http://onlinelibrary.wiley.com/doi/10.1111/j.1756-185X.2012.01815.x/abstract | - |
dc.subject.keyword | Adult | - |
dc.subject.keyword | Aged | - |
dc.subject.keyword | Arthritis, Rheumatoid/blood | - |
dc.subject.keyword | Arthritis, Rheumatoid/epidemiology | - |
dc.subject.keyword | Arthritis, Rheumatoid/physiopathology | - |
dc.subject.keyword | Data Collection | - |
dc.subject.keyword | Female | - |
dc.subject.keyword | Hemodynamics/physiology | - |
dc.subject.keyword | Humans | - |
dc.subject.keyword | Hypertension, Pulmonary/blood* | - |
dc.subject.keyword | Hypertension, Pulmonary/epidemiology | - |
dc.subject.keyword | Hypertension, Pulmonary/physiopathology* | - |
dc.subject.keyword | Lupus Erythematosus, Systemic/blood | - |
dc.subject.keyword | Lupus Erythematosus, Systemic/epidemiology | - |
dc.subject.keyword | Lupus Erythematosus, Systemic/physiopathology | - |
dc.subject.keyword | Male | - |
dc.subject.keyword | Middle Aged | - |
dc.subject.keyword | Mixed Connective Tissue Disease/blood | - |
dc.subject.keyword | Mixed Connective Tissue Disease/epidemiology | - |
dc.subject.keyword | Mixed Connective Tissue Disease/physiopathology | - |
dc.subject.keyword | Natriuretic Peptide, Brain/blood | - |
dc.subject.keyword | Peptide Fragments/blood | - |
dc.subject.keyword | Pulmonary Diffusing Capacity/physiology | - |
dc.subject.keyword | Registries* | - |
dc.subject.keyword | Republic of Korea/epidemiology | - |
dc.subject.keyword | Retrospective Studies | - |
dc.subject.keyword | Rheumatic Diseases/complications* | - |
dc.subject.keyword | Scleroderma, Systemic/blood | - |
dc.subject.keyword | Scleroderma, Systemic/epidemiology | - |
dc.subject.keyword | Scleroderma, Systemic/physiopathology | - |
dc.contributor.alternativeName | Lee, Soo Kon | - |
dc.contributor.affiliatedAuthor | Lee, Soo Kon | - |
dc.citation.volume | 15 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 80 | - |
dc.citation.endPage | 89 | - |
dc.identifier.bibliographicCitation | INTERNATIONAL JOURNAL OF RHEUMATIC DISEASES, Vol.15(5) : 80-89, 2012 | - |
dc.identifier.rimsid | 32824 | - |
dc.type.rims | ART | - |
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