2 218

Cited 0 times in

MGMT gene promoter methylation as a potent prognostic factor in glioblastoma treated with temozolomide-based chemoradiotherapy: a single-institution study.

Authors
 Young Suk Kim  ;  Se Hoon Kim  ;  Jaeho Cho  ;  Jun Won Kim  ;  Jong Hee Chang  ;  Dong Suk Kim  ;  Kyu Sung Lee  ;  Chang-Ok Suh 
Citation
 INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, Vol.84(3) : 661-667, 2012 
Journal Title
 INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS 
ISSN
 0360-3016 
Issue Date
2012
MeSH
Adult ; Age Factors ; Aged ; Antineoplastic Agents, Alkylating/therapeutic use ; Brain Neoplasms/genetics* ; Brain Neoplasms/mortality* ; Brain Neoplasms/therapy ; DNA Methylation* ; DNA Modification Methylases/genetics* ; DNA Modification Methylases/metabolism ; DNA Repair Enzymes/genetics* ; DNA Repair Enzymes/metabolism ; Dacarbazine/analogs & derivatives ; Dacarbazine/therapeutic use ; Disease-Free Survival ; Female ; Glioblastoma/genetics* ; Glioblastoma/mortality* ; Glioblastoma/therapy ; Humans ; Male ; Middle Aged ; Multivariate Analysis ; Prognosis ; Promoter Regions, Genetic/genetics* ; Radiotherapy, Conformal ; Reoperation ; Retrospective Studies ; Tumor Suppressor Proteins/genetics* ; Tumor Suppressor Proteins/metabolism
Keywords
Glioblastoma ; O6-methylguanine-DNA methyltransferase ; Methylation ; Prognostic factor ; Radiotherapy
Abstract
PURPOSE: Recently, cells deficient in O(6)-methylguanine-DNA methyltransferase (MGMT) were found to show increased sensitivity to temozolomide (TMZ). We evaluated whether hypermethylation of MGMT was associated with survival in patients with glioblastoma multiforme (GBM). METHODS AND MATERIALS: We retrospectively analyzed 93 patients with histologically confirmed GBM who received involved-field radiotherapy with TMZ from 2001 to 2008. The median age was 58 years (range, 24-78 years). Surgical resection was total in 39 patients (42%), subtotal in 30 patients (32%), and partial in 17 patients (18%); only a biopsy was performed in 7 patients (8%). Postoperative radiotherapy began within 3 weeks of surgery in 87% of the patients. Radiotherapy doses ranged from 50 to 74 Gy (median, 70 Gy). MGMT gene methylation was determined in 78 patients; MGMT was unmethylated in 43 patients (55%) and methylated in 35 patients (45%). The median follow-up period was 22 months (range, 3-88 months) for all patients. RESULTS: The median overall survival (OS) was 22 months, and progression-free survival (PFS) was 11 months. MGMT gene methylation was an independently significant prognostic factor for both OS (p = 0.002) and PFS (p = 0.008) in multivariate analysis. The median OS was 29 months for the methylated group and 20 months for the unmethylated group. In 35 patients with methylated MGMT genes, the 2-year and 5-year OS rates were 54% and 31%, respectively. Six patients with combined prognostic factors of methylated MGMT genes, age ≤50 years, and total/subtotal resections are all alive 38 to 77 months after operation, whereas the median OS in 8 patients with unmethylated MGMT genes, age >50 years, and less than subtotal resection was 13.2 months. CONCLUSION: We confirmed that MGMT gene methylation is a potent prognostic factor in patients with GBM. Our results suggest that early postoperative radiotherapy and a high total/subtotal resection rate might further improve the outcome.
Full Text
http://www.sciencedirect.com/science/article/pii/S0360301611038120
DOI
22414280
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiation Oncology (방사선종양학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Neurosurgery (신경외과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Dong Seok(김동석)
Kim, Se Hoon(김세훈) ORCID logo https://orcid.org/0000-0001-7516-7372
Kim, Jun Won(김준원) ORCID logo https://orcid.org/0000-0003-1358-364X
Suh, Chang Ok(서창옥)
Lee, Kyu Sung(이규성)
Chang, Jong Hee(장종희)
Cho, Jae Ho(조재호) ORCID logo https://orcid.org/0000-0001-9966-5157
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/90537
사서에게 알리기
  feedback

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse