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EGCG suppresses prostate cancer cell growth modulating acetylation of androgen receptor by anti-histone acetyltransferase activity.

Authors
 Yoo-Hyun Lee  ;  Jieun Kwak  ;  Hyo-Kyoung Choi  ;  Kyung-Chul Choi  ;  Sunoh Kim  ;  Jeongmin Lee  ;  Woojin Jun  ;  Hyun-Jin Park  ;  Ho-Geun Yoon 
Citation
 INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE, Vol.30(1) : 69-74, 2012 
Journal Title
 INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE 
ISSN
 1107-3756 
Issue Date
2012
MeSH
Acetylation/drug effects ; Androgen Receptor Antagonists/pharmacology* ; Antineoplastic Agents/metabolism ; Antineoplastic Agents/pharmacology ; Apoptosis/drug effects ; Catechin/analogs & derivatives* ; Catechin/metabolism ; Catechin/pharmacology ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Chemoprevention ; Histone Acetyltransferases/antagonists & inhibitors* ; Histone Acetyltransferases/metabolism ; Humans ; Male ; Prostatic Neoplasms/drug therapy* ; Prostatic Neoplasms/metabolism ; Prostatic Neoplasms/prevention & control ; Receptors, Androgen/metabolism* ; Transcription, Genetic/drug effects
Keywords
Acetylation/drug effects ; Androgen Receptor Antagonists/pharmacology* ; Antineoplastic Agents/metabolism ; Antineoplastic Agents/pharmacology ; Apoptosis/drug effects ; Catechin/analogs & derivatives* ; Catechin/metabolism ; Catechin/pharmacology ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Chemoprevention ; Histone Acetyltransferases/antagonists & inhibitors* ; Histone Acetyltransferases/metabolism ; Humans ; Male ; Prostatic Neoplasms/drug therapy* ; Prostatic Neoplasms/metabolism ; Prostatic Neoplasms/prevention & control ; Receptors, Androgen/metabolism* ; Transcription, Genetic/drug effects
Abstract
Manipulating acetylation status of key gene targets is likely to be crucial for effective cancer therapy. In this study, we utilized green tea catechins, epicatechin (EC), epigallocatechin (EGC) and epigallocatechin-3-gallate (EGCG) to examine the regulation of androgen receptor acetylation in androgen-dependent prostate cancer cells by histone acetyl-transferase (HAT) activity. EC, EGC and EGCG induced prostate cancer cell death, suppressed agonist-dependent androgen receptor (AR) activation and AR-regulated gene transcription. These results demonstrated a similar tendency to HAT inhibitory activities; EGCG>EGC>EC. The strongest HAT inhibitor among them, EGCG (50 µM), downregulated AR acetylation and finally, AR protein translocation to nucleus from the cytoplasmic compartment was effectively inhibited in the presence of the agonist. These results suggest another mechanism to develop effective therapeutics based on green tea catechins.
Full Text
http://www.spandidos-publications.com/ijmm/30/1/69
DOI
22505206
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Biochemistry and Molecular Biology (생화학-분자생물학교실) > 1. Journal Papers
Yonsei Authors
Yoon, Ho Geun(윤호근) ORCID logo https://orcid.org/0000-0003-2718-3372
Choi, Hyo Kyoung(최효경)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/90495
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