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Allele frequencies of human leukocyte antigen-G in a Korean population.

Authors
 Y. Park  ;  Y. S. Kim  ;  O. J. Kwon  ;  H.-S. Kim 
Citation
 INTERNATIONAL JOURNAL OF IMMUNOGENETICS, Vol.39(1) : 39-45, 2012 
Journal Title
 INTERNATIONAL JOURNAL OF IMMUNOGENETICS 
ISSN
 1744-3121 
Issue Date
2012
MeSH
Alleles ; Asian Continental Ancestry Group/ethnology ; Asian Continental Ancestry Group/genetics ; Base Sequence ; Exons ; Gene Frequency* ; Genetics, Population* ; Genome, Human ; Genotype ; HLA-A Antigens/genetics ; HLA-B Antigens/genetics ; HLA-C Antigens/genetics ; HLA-G Antigens/genetics* ; Humans ; INDEL Mutation ; Linkage Disequilibrium ; Polymorphism, Genetic*
Keywords
Alleles ; Asian Continental Ancestry Group/ethnology ; Asian Continental Ancestry Group/genetics ; Base Sequence ; Exons ; Gene Frequency* ; Genetics, Population* ; Genome, Human ; Genotype ; HLA-A Antigens/genetics ; HLA-B Antigens/genetics ; HLA-C Antigens/genetics ; HLA-G Antigens/genetics* ; Humans ; INDEL Mutation ; Linkage Disequilibrium ; Polymorphism, Genetic*
Abstract
The human leukocyte antigen (HLA)-G is a nonclassical major histocompatibility complex class I molecule with relatively limited polymorphism. The differences in allele frequency according to ethnicity and country have not been studied enough, so far. Therefore, fundamental data including allele frequencies and polymorphism are needed for studies on immunological function of HLA-G in each population. We investigated allele frequencies and 14-bp polymorphism of the HLA-G in Koreans. HLA-G alleles and 14-bp polymorphisms were determined by sequence-based typing analysis of exons 2-4 and polymerase chain reaction of exon 8 in 200 unrelated individuals. Genotyping analysis identified eight different HLA-G alleles, which indicates that the Korean population presents limited HLA-G allelic polymorphism. HLA-G*01:01:01:01 and G*01:04:01 were frequent alleles (42.5% and 34.0%), and allelic frequencies were similar to those of other Asian populations. The 14-bp deletion alleles are higher (78%) in Koreans, although the frequencies of the 14-bp insertion/deletion polymorphism have been known to be nearly equal in many Caucasian populations. HLA-G*01:01:08 was reported strong linkage disequilibrium with the 14-bp deletion in a previous report; the same allele was accompanied with 14-bp insertion in our study. There are a few studies investigating allele frequencies, and most of them were studied before high-resolution method era. This is the first study regarding HLA-G genotypes in Korean, which were identified by high-resolution method. From this study, we identified HLA-G frequencies of a Korean population and expect this study could help further investigations for immunological and clinical implications of HLA-G.
Full Text
http://onlinelibrary.wiley.com/doi/10.1111/j.1744-313X.2011.01053.x/abstract
DOI
22035429
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Laboratory Medicine (진단검사의학교실) > 1. Journal Papers
Yonsei Authors
Kim, Yu Seun(김유선) ORCID logo https://orcid.org/0000-0002-5105-1567
Kim, Hyon Suk(김현숙) ORCID logo https://orcid.org/0000-0001-5662-7740
Park, Yong Jung(박용정)
Park, Youn Hee(박윤희) ORCID logo https://orcid.org/0000-0001-8458-1495
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/90477
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