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Waldeyer's ring marginal zone B cell lymphoma: Are the clinical and prognostic features nodal or extranodal? A study by the Consortium for Improving Survival of Lymphoma (CISL)

Authors
 Sung Yong Oh  ;  Won Seog Kim  ;  Jin Seok Kim  ;  Seok Jin Kim  ;  Suee Lee  ;  Dae Ho Lee  ;  Soon Il Lee  ;  Hye Jin Kang  ;  Chul Won Choi  ;  Jinny Park  ;  Moo Kon Song  ;  Hyo Jung Kim  ;  Jung Hye Kwon  ;  Jae-Yong Kwak  ;  Sung Hwa Bae  ;  Byeong-Bae Park  ;  Young-Rok Do  ;  Ho Sup Lee  ;  Seong Hyun Jeong  ;  Cheolwon Suh  ;  Hyo-Jin Kim 
Citation
 INTERNATIONAL JOURNAL OF HEMATOLOGY, Vol.96(5) : 631-637, 2012 
Journal Title
 INTERNATIONAL JOURNAL OF HEMATOLOGY 
ISSN
 0925-5710 
Issue Date
2012
MeSH
Adolescent ; Adult ; Aged ; Aged, 80 and over ; Antineoplastic Combined Chemotherapy Protocols/administration & dosage ; Cyclophosphamide/administration & dosage ; Disease-Free Survival ; Doxorubicin/administration & dosage ; Female ; Follow-Up Studies ; Humans ; Lymphoma, B-Cell, Marginal Zone/mortality* ; Lymphoma, B-Cell, Marginal Zone/pathology* ; Lymphoma, B-Cell, Marginal Zone/therapy ; Male ; Middle Aged ; Prednisone/administration & dosage ; Retrospective Studies ; Survival Rate ; Tonsillar Neoplasms/mortality* ; Tonsillar Neoplasms/pathology* ; Tonsillar Neoplasms/therapy ; Vincristine/administration & dosage
Keywords
Waldeyer’s ring ; Marginal zone ; Lymphoma
Abstract
There has been controversy surrounding Waldeyer’s ring (WR), especially focused on the question of whether it should be regarded as a nodal or an extranodal site. We conducted retrospective analyses of marginal zone B cell lymphomas involving WR (WR-MZLs) to observe their clinical features and prognosis, with specific regard to the nodal-or-extranodal question. A total of 52 patients with histological diagnosis of WR-MZL were retrospectively analyzed. The most common involvement site was the tonsil (40.4 %). Ann Arbor stage III/VI disease was present in 48.1 % (25 of 52). The response rate of the 27 stage I/II patients was 88.9 %, with 21 complete remissions and three partial remissions. The median time to progression (TTP) was 3.7 years (95 % CI 2.5–4.9 years). The estimated 5-year TTP and overall survival rates were 39.4 and 90.5 %, respectively. In a comparison with the historical data regarding extra-WR MALT lymphoma and nodal MZL (N-MZL), MALT lymphoma showed better TTP results than did WR-MZL and N-MZL (P < 0.001).
Full Text
http://link.springer.com/article/10.1007%2Fs12185-012-1200-0
DOI
23065471
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Jin Seok(김진석) ORCID logo https://orcid.org/0000-0001-8986-8436
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/90475
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