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Major determinants for the uncovered stent struts on optical coherence tomography after drug-eluting stent implantation.

Authors
 Byeong-Keuk Kim  ;  Jung-Sun Kim  ;  Changmyung Oh  ;  Young-Guk Ko  ;  Donghoon Choi  ;  Yangsoo Jang  ;  Myeong-Ki Hong 
Citation
 INTERNATIONAL JOURNAL OF CARDIOVASCULAR IMAGING, Vol.28(4) : 705-714, 2012 
Journal Title
 INTERNATIONAL JOURNAL OF CARDIOVASCULAR IMAGING 
ISSN
 1569-5794 
Issue Date
2012
MeSH
Aged ; Analysis of Variance ; Angioplasty, Balloon, Coronary/adverse effects ; Angioplasty, Balloon, Coronary/instrumentation* ; Cardiovascular Agents/administration & dosage ; Coronary Artery Disease/pathology ; Coronary Artery Disease/therapy* ; Coronary Restenosis/etiology ; Coronary Restenosis/pathology ; Coronary Restenosis/prevention & control ; Coronary Thrombosis/etiology ; Coronary Thrombosis/pathology ; Coronary Thrombosis/prevention & control ; Coronary Vessels/pathology* ; Drug-Eluting Stents* ; Everolimus ; Female ; Humans ; Logistic Models ; Male ; Middle Aged ; Odds Ratio ; Paclitaxel/administration & dosage ; Predictive Value of Tests ; Prosthesis Design ; Registries ; Republic of Korea ; Risk Assessment ; Risk Factors ; Sirolimus/administration & dosage ; Sirolimus/analogs & derivatives ; Time Factors ; Tomography, Optical Coherence* ; Treatment Outcome
Keywords
Optical coherence tomography ; Stent
Abstract
There have been little data regarding major determinants for the uncovered stent struts after drug-eluting stent (DES) implantation on optical coherence tomography (OCT). We investigated the major determinants of incomplete neointimal coverage of DES struts on OCT after implantation in a large cohort of patients. A total of 261 patients with 279 lesions who were treated with various DESs were selected from the OCT registry database. The lesions were divided into two groups based on the ratio of uncovered struts to total struts in all OCT cross-sections; an uncovered group (highest quartile with % uncovered struts ≥5.4%, n = 70), and covered group (the remaining lower quartiles with % uncovered struts <5.4%, n = 209). The uncovered group was more likely to have complex lesions, smaller reference vessel and stent diameter, and longer stent, more use of sirolimus-eluting stents, and less use of zotarolimus-eluting stents compared with the covered group. Of these variables, the most significant determinant of uncovered stent struts was DES type (odds ratio [OR] = 2.75, 95% confidence interval [CI] = 1.94-3.89, P < 0.001). The use of sirolimus-eluting stents (OR = 2.44, 95% CI, 1.15-5.47, P = 0.023) and zotarolimus-eluting stents (OR = 0.02, 95% CI = 0.01-0.25, P = 0.002) were the only significant risk and protective factors for uncovered stent struts, respectively. This study demonstrated that DES type might be associated with the most important determinants of uncovered struts compared to any other clinical or angiographic factor.
Full Text
http://link.springer.com/article/10.1007%2Fs10554-011-9896-0
DOI
21626042
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Ko, Young Guk(고영국) ORCID logo https://orcid.org/0000-0001-7748-5788
Kim, Byeong Keuk(김병극) ORCID logo https://orcid.org/0000-0003-2493-066X
Kim, Jung Sun(김중선) ORCID logo https://orcid.org/0000-0003-2263-3274
Oh, Chang Myung(오창명)
Jang, Yang Soo(장양수) ORCID logo https://orcid.org/0000-0002-2169-3112
Choi, Dong Hoon(최동훈) ORCID logo https://orcid.org/0000-0002-2009-9760
Hong, Myeong Ki(홍명기) ORCID logo https://orcid.org/0000-0002-2090-2031
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/90454
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