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A Flexible Depth Probe Using Liquid Crystal Polymer

Authors
 Sung Eun Lee  ;  Sang Beom Jun  ;  Hyun Joo Lee  ;  Jinhyung Kim  ;  Seung Woo Lee  ;  Changkyun Im  ;  Hyung-Cheul Shin  ;  Jin Woo Chang  ;  Sung June Kim 
Citation
 IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING, Vol.59(7) : 2085-2094, 2012 
Journal Title
IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING
ISSN
 0018-9294 
Issue Date
2012
MeSH
Animals ; Brain/physiology* ; Brain/surgery* ; Electrodes, Implanted* ; Neurons/physiology* ; Neurosurgical Procedures/instrumentation* ; Polymers/chemistry* ; Rats ; Rats, Sprague-Dawley ; Signal Processing, Computer-Assisted ; Silicon/chemistry
Keywords
Liquid crystal polymer (LCP) ; neural depth probe ; polymer-based depth probe
Abstract
We proposed a method of making a flexible depth-type neural probe using liquid crystal polymer. Conventional depth neural probes made of metal or silicon have the limitations of a single recording site per shank or the brittleness of the silicon substrate. To avoid these drawbacks, polymer-based depth neural probes have been developed with biocompatible polymers such as polyimides or parylenes. However, those have suffered from the difficulty of inserting the probes into brain tissues due to their high flexibility, requiring mechanical reinforcements. Herein, we report the first attempt to use a flexible material, liquid crystal polymer (LCP), as a substrate for a depth-type neural probe. The LCP-based probe offers a controllable stiffness vs. flexibility and compatibility with thin-film processes in addition to its inherent characteristics such as high reliability and biocompatibility. In the present study, an LCP neural probe was fabricated to have enough stiffness to penetrate the dura mater of rodent brains without a guide tool or additional reinforcement structures. A simultaneous multichannel neural recording was successfully achieved from the somatosensory motor cortex of the rodents. Immunohistochemistry showed that the electrodes could be inserted into the desired regions in the brain.
Full Text
http://ieeexplore.ieee.org/xpl/articleDetails.jsp?arnumber=6218195
DOI
22718688
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Neurosurgery (신경외과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원) > 1. Journal Papers
Yonsei Authors
Kim, Jin Hyung(김진형)
Chang, Jin Woo(장진우) ORCID logo https://orcid.org/0000-0002-2717-0101
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/90387
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