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Role of transcription factor modifications in the pathogenesis of insulin resistance

Authors
 Mi-Young Kim  ;  Jin-Sik Bae  ;  Tae-Hyun Kim  ;  Joo-Man Park  ;  Yong Ho Ahn 
Citation
 EXPERIMENTAL DIABETES RESEARCH, Vol.2012 : 716425, 2012 
Journal Title
 EXPERIMENTAL DIABETES RESEARCH 
ISSN
 1687-5214 
Issue Date
2012
MeSH
Adipokines/physiology ; Animals ; DNA/metabolism ; Diabetes Mellitus, Type 2/complications ; Diabetes Mellitus, Type 2/physiopathology ; Fatty Acids, Nonesterified/physiology ; Fatty Liver/complications ; Fatty Liver/physiopathology* ; Humans ; Insulin Resistance/physiology* ; Insulin-Secreting Cells/physiology ; Liver/metabolism ; Macrophages/physiology ; Metabolic Syndrome/complications ; Metabolic Syndrome/physiopathology ; Non-alcoholic Fatty Liver Disease ; Protein Processing, Post-Translational* ; Transcription Factors/metabolism*
Keywords
Adipokines/physiology ; Animals ; DNA/metabolism ; Diabetes Mellitus, Type 2/complications ; Diabetes Mellitus, Type 2/physiopathology ; Fatty Acids, Nonesterified/physiology ; Fatty Liver/complications ; Fatty Liver/physiopathology* ; Humans ; Insulin Resistance/physiology* ; Insulin-Secreting Cells/physiology ; Liver/metabolism ; Macrophages/physiology ; Metabolic Syndrome/complications ; Metabolic Syndrome/physiopathology ; Non-alcoholic Fatty Liver Disease ; Protein Processing, Post-Translational* ; Transcription Factors/metabolism*
Abstract
Non-alcoholic fatty liver disease (NAFLD) is characterized by fat accumulation in the liver not due to alcohol abuse. NAFLD is accompanied by variety of symptoms related to metabolic syndrome. Although the metabolic link between NAFLD and insulin resistance is not fully understood, it is clear that NAFLD is one of the main cause of insulin resistance. NAFLD is shown to affect the functions of other organs, including pancreas, adipose tissue, muscle and inflammatory systems. Currently efforts are being made to understand molecular mechanism of interrelationship between NAFLD and insulin resistance at the transcriptional level with specific focus on post-translational modification (PTM) of transcription factors. PTM of transcription factors plays a key role in controlling numerous biological events, including cellular energy metabolism, cell-cycle progression, and organ development. Cell type- and tissue-specific reversible modifications include lysine acetylation, methylation, ubiquitination, and SUMOylation. Moreover, phosphorylation and O-GlcNAcylation on serine and threonine residues have been shown to affect protein stability, subcellular distribution, DNA-binding affinity, and transcriptional activity. PTMs of transcription factors involved in insulin-sensitive tissues confer specific adaptive mechanisms in response to internal or external stimuli. Our understanding of the interplay between these modifications and their effects on transcriptional regulation is growing. Here, we summarize the diverse roles of PTMs in insulin-sensitive tissues and their involvement in the pathogenesis of insulin resistance.
Files in This Item:
T201205102.pdf Download
DOI
22110478
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Biochemistry and Molecular Biology (생화학-분자생물학교실) > 1. Journal Papers
Yonsei Authors
Kim, Mi Young(김미영)
Kim, Tae Hyun(김태현)
Park, Joo Man(박주만)
Bae, Jin Sik(배진식)
Ahn, Yong Ho(안용호) ORCID logo https://orcid.org/0000-0002-4133-0757
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/90280
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