148 367

Cited 0 times in

Role of transcription factor modifications in the pathogenesis of insulin resistance

DC FieldValueLanguage
dc.contributor.author김미영-
dc.contributor.author김태현-
dc.contributor.author박주만-
dc.contributor.author배진식-
dc.contributor.author안용호-
dc.date.accessioned2014-12-19T16:50:00Z-
dc.date.available2014-12-19T16:50:00Z-
dc.date.issued2012-
dc.identifier.issn1687-5214-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/90280-
dc.description.abstractNon-alcoholic fatty liver disease (NAFLD) is characterized by fat accumulation in the liver not due to alcohol abuse. NAFLD is accompanied by variety of symptoms related to metabolic syndrome. Although the metabolic link between NAFLD and insulin resistance is not fully understood, it is clear that NAFLD is one of the main cause of insulin resistance. NAFLD is shown to affect the functions of other organs, including pancreas, adipose tissue, muscle and inflammatory systems. Currently efforts are being made to understand molecular mechanism of interrelationship between NAFLD and insulin resistance at the transcriptional level with specific focus on post-translational modification (PTM) of transcription factors. PTM of transcription factors plays a key role in controlling numerous biological events, including cellular energy metabolism, cell-cycle progression, and organ development. Cell type- and tissue-specific reversible modifications include lysine acetylation, methylation, ubiquitination, and SUMOylation. Moreover, phosphorylation and O-GlcNAcylation on serine and threonine residues have been shown to affect protein stability, subcellular distribution, DNA-binding affinity, and transcriptional activity. PTMs of transcription factors involved in insulin-sensitive tissues confer specific adaptive mechanisms in response to internal or external stimuli. Our understanding of the interplay between these modifications and their effects on transcriptional regulation is growing. Here, we summarize the diverse roles of PTMs in insulin-sensitive tissues and their involvement in the pathogenesis of insulin resistance.-
dc.description.statementOfResponsibilityopen-
dc.formatapplication/pdf-
dc.relation.isPartOfEXPERIMENTAL DIABETES RESEARCH-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdipokines/physiology-
dc.subject.MESHAnimals-
dc.subject.MESHDNA/metabolism-
dc.subject.MESHDiabetes Mellitus, Type 2/complications-
dc.subject.MESHDiabetes Mellitus, Type 2/physiopathology-
dc.subject.MESHFatty Acids, Nonesterified/physiology-
dc.subject.MESHFatty Liver/complications-
dc.subject.MESHFatty Liver/physiopathology*-
dc.subject.MESHHumans-
dc.subject.MESHInsulin Resistance/physiology*-
dc.subject.MESHInsulin-Secreting Cells/physiology-
dc.subject.MESHLiver/metabolism-
dc.subject.MESHMacrophages/physiology-
dc.subject.MESHMetabolic Syndrome/complications-
dc.subject.MESHMetabolic Syndrome/physiopathology-
dc.subject.MESHNon-alcoholic Fatty Liver Disease-
dc.subject.MESHProtein Processing, Post-Translational*-
dc.subject.MESHTranscription Factors/metabolism*-
dc.titleRole of transcription factor modifications in the pathogenesis of insulin resistance-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Biochemistry & Molecular Biology (생화학,분자생물학)-
dc.contributor.googleauthorMi-Young Kim-
dc.contributor.googleauthorJin-Sik Bae-
dc.contributor.googleauthorTae-Hyun Kim-
dc.contributor.googleauthorJoo-Man Park-
dc.contributor.googleauthorYong Ho Ahn-
dc.identifier.doi22110478-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA00446-
dc.contributor.localIdA01666-
dc.contributor.localIdA01809-
dc.contributor.localIdA02249-
dc.contributor.localIdA01081-
dc.relation.journalcodeJ00867-
dc.identifier.eissn1687-5303-
dc.identifier.pmid22110478-
dc.subject.keywordAdipokines/physiology-
dc.subject.keywordAnimals-
dc.subject.keywordDNA/metabolism-
dc.subject.keywordDiabetes Mellitus, Type 2/complications-
dc.subject.keywordDiabetes Mellitus, Type 2/physiopathology-
dc.subject.keywordFatty Acids, Nonesterified/physiology-
dc.subject.keywordFatty Liver/complications-
dc.subject.keywordFatty Liver/physiopathology*-
dc.subject.keywordHumans-
dc.subject.keywordInsulin Resistance/physiology*-
dc.subject.keywordInsulin-Secreting Cells/physiology-
dc.subject.keywordLiver/metabolism-
dc.subject.keywordMacrophages/physiology-
dc.subject.keywordMetabolic Syndrome/complications-
dc.subject.keywordMetabolic Syndrome/physiopathology-
dc.subject.keywordNon-alcoholic Fatty Liver Disease-
dc.subject.keywordProtein Processing, Post-Translational*-
dc.subject.keywordTranscription Factors/metabolism*-
dc.contributor.alternativeNameKim, Mi Young-
dc.contributor.alternativeNameKim, Tae Hyun-
dc.contributor.alternativeNamePark, Joo Man-
dc.contributor.alternativeNameBae, Jin Sik-
dc.contributor.alternativeNameAhn, Yong Ho-
dc.contributor.affiliatedAuthorKim, Mi Young-
dc.contributor.affiliatedAuthorPark, Joo Man-
dc.contributor.affiliatedAuthorBae, Jin Sik-
dc.contributor.affiliatedAuthorAhn, Yong Ho-
dc.contributor.affiliatedAuthorKim, Tae Hyun-
dc.citation.volume2012-
dc.citation.startPage716425-
dc.identifier.bibliographicCitationEXPERIMENTAL DIABETES RESEARCH, Vol.2012 : 716425, 2012-
dc.identifier.rimsid34113-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Biochemistry and Molecular Biology (생화학-분자생물학교실) > 1. Journal Papers

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.