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Changes in cytokine expression after electroacupuncture in neuropathic rats

Authors
 Myeoung Hoon Cha  ;  Taick Sang Nam  ;  Yongho Kwak  ;  Hyejung Lee  ;  Bae Hwan Lee 
Citation
 EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE, Vol.2012 : 792765, 2012 
Journal Title
 EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE 
ISSN
 1741-427X 
Issue Date
2012
Abstract
The production of proinflammatory cytokines including interleukin-1 (IL-1), interleukin-6 (IL-6), and tumor necrosis factor-α (TNF-α) plays a key role in chronic pain such as neuropathic pain. We investigated changes in cytokine expression in injured peripheral nerves and dorsal root ganglia (DRG) following electroacupuncture (EA) treatment. Neuropathic pain was induced by peripheral nerve injury to the left hind limb of Sprague-Dawley rats under pentobarbital anesthesia. Two weeks later, the nerve-injured rats were treated by EA for 10 minutes. The expression levels of IL-1β, IL-6, and TNF-α in peripheral nerves and DRG of neuropathic rats were significantly increased in nerve-injured rats. However, after EA, the cytokine expression levels were noticeably decreased in peripheral nerves and DRG. These results suggest that EA stimulation can reduce the levels of proinflamtory cytokines elevated after nerve injury.
Files in This Item:
T201200977.pdf Download
DOI
22454684
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Physiology (생리학교실) > 1. Journal Papers
Yonsei Authors
Kwak, Yong Ho(곽용호)
Nam, Taick Sang(남택상)
Lee, Bae Hwan(이배환) ORCID logo https://orcid.org/0000-0003-4719-9021
Cha, Myeoung Hoon(차명훈) ORCID logo https://orcid.org/0000-0002-7993-672X
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/90258
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