Cited 188 times in
Triple-negative invasive breast cancer on dynamic contrast-enhanced and diffusion-weighted MR imaging: comparison with other breast cancer subtypes.
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 정진 | - |
dc.contributor.author | 김은경 | - |
dc.contributor.author | 김정아 | - |
dc.contributor.author | 손은주 | - |
dc.contributor.author | 육지현 | - |
dc.date.accessioned | 2014-12-19T16:49:09Z | - |
dc.date.available | 2014-12-19T16:49:09Z | - |
dc.date.issued | 2012 | - |
dc.identifier.issn | 0938-7994 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/90253 | - |
dc.description.abstract | OBJECTIVES: To determine the MRI features of triple-negative invasive breast cancer (TNBC) on dynamic contrast-enhanced MR imaging (DCE-MRI) and diffusion-weighted MR imaging (DWI) in comparison with ER-positive/HER2-negative (ER+) and HER2-positive cancer (HER2+). METHODS: A total of 271 invasive cancers in 269 patients undergoing preoperative MRI and surgery were included. Two radiologists retrospectively assessed morphological and kinetic characteristics on DCE-MRI and tumour detectability on DWI. Apparent diffusion coefficient (ADC) values of lesions were measured. Clinical and MRI features of the three subtypes were compared. RESULTS: Compared with ER+ (n = 119) and HER2+ (n = 94), larger size, round/oval mass shape, smooth mass margin, and rim enhancement on DCE-MRI were significantly associated with TNBC (n = 58; P < 0.0001). On DWI, mean ADC value (× 10(-3) mm(2)/s) of TNBC (1.03) was higher than the mean ADC values for ER+ and HER2+ (0.89 and 0.84; P < 0.0001). There was no difference in tumour detectability (P = 0.099). Tumour size (P = 0.009), mass margin (smooth, P < 0.0001; irregular, P = 0.020), and ADC values (P = 0.002) on DCE-MRI and DWI were independent features of TNBC. CONCLUSIONS: In addition to the morphological features, higher ADC values on DWI were independently associated with TNBC and could be useful in differentiating TNBC from ER+ and HER2+. KEY POINTS: • Triple-negative breast cancers (TNBC) lack oestrogen/progesterone receptors and HER2 expression/amplification. • TNBCs are larger, better defined and more necrotic than conventional cancers. • On MRI, necrosis yields high T2-weighted signal intensity and ADCs. • High ADC values can be useful in diagnosing TNBC. | - |
dc.description.statementOfResponsibility | open | - |
dc.relation.isPartOf | EUROPEAN RADIOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Aged, 80 and over | - |
dc.subject.MESH | Breast Neoplasms/diagnosis* | - |
dc.subject.MESH | Breast Neoplasms/metabolism* | - |
dc.subject.MESH | Breast Neoplasms/pathology | - |
dc.subject.MESH | Contrast Media/pharmacology | - |
dc.subject.MESH | Diffusion | - |
dc.subject.MESH | Diffusion Magnetic Resonance Imaging/methods* | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Kinetics | - |
dc.subject.MESH | Magnetic Resonance Imaging/methods* | - |
dc.subject.MESH | Medical Oncology/methods | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Necrosis | - |
dc.subject.MESH | Neoplasm Invasiveness | - |
dc.subject.MESH | Receptor, ErbB-2/biosynthesis* | - |
dc.subject.MESH | Receptors, Estrogen/biosynthesis* | - |
dc.subject.MESH | Retrospective Studies | - |
dc.title | Triple-negative invasive breast cancer on dynamic contrast-enhanced and diffusion-weighted MR imaging: comparison with other breast cancer subtypes. | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Radiology (영상의학) | - |
dc.contributor.googleauthor | Ji Hyun Youk | - |
dc.contributor.googleauthor | Eun Ju Son | - |
dc.contributor.googleauthor | Jin Chung | - |
dc.contributor.googleauthor | Jeong-Ah Kim | - |
dc.contributor.googleauthor | Eun-kyung Kim | - |
dc.identifier.doi | 10.1007/s00330-012-2425-2 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A03740 | - |
dc.contributor.localId | A00801 | - |
dc.contributor.localId | A00888 | - |
dc.contributor.localId | A01988 | - |
dc.contributor.localId | A02537 | - |
dc.relation.journalcode | J00851 | - |
dc.identifier.eissn | 1432-1084 | - |
dc.identifier.pmid | 22527371 | - |
dc.identifier.url | http://link.springer.com/article/10.1007%2Fs00330-012-2425-2 | - |
dc.subject.keyword | Breast | - |
dc.subject.keyword | MRI | - |
dc.subject.keyword | Contrast-enhanced imaging | - |
dc.subject.keyword | Diffusion-weighted imaging | - |
dc.subject.keyword | Triple-negative breast cancer | - |
dc.contributor.alternativeName | Chung, Jin | - |
dc.contributor.alternativeName | Kim, Eun Kyung | - |
dc.contributor.alternativeName | Kim, Jeong Ah | - |
dc.contributor.alternativeName | Son, Eun Ju | - |
dc.contributor.alternativeName | Youk, Ji Hyun | - |
dc.contributor.affiliatedAuthor | Chung, Jin | - |
dc.contributor.affiliatedAuthor | Kim, Eun-Kyung | - |
dc.contributor.affiliatedAuthor | Kim, Jeong Ah | - |
dc.contributor.affiliatedAuthor | Son, Eun Ju | - |
dc.contributor.affiliatedAuthor | Youk, Ji Hyun | - |
dc.citation.volume | 22 | - |
dc.citation.number | 8 | - |
dc.citation.startPage | 1724 | - |
dc.citation.endPage | 1734 | - |
dc.identifier.bibliographicCitation | EUROPEAN RADIOLOGY, Vol.22(8) : 1724-1734, 2012 | - |
dc.identifier.rimsid | 34095 | - |
dc.type.rims | ART | - |
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