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Prediction of the histopathological grade of hepatocellular carcinoma using qualitative diffusion-weighted, dynamic, and hepatobiliary phase MRI.
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김기황 | - |
dc.contributor.author | 김명진 | - |
dc.contributor.author | 김여은 | - |
dc.contributor.author | 박미숙 | - |
dc.contributor.author | 정용은 | - |
dc.contributor.author | 정우석 | - |
dc.contributor.author | 안찬식 | - |
dc.date.accessioned | 2014-12-19T16:49:07Z | - |
dc.date.available | 2014-12-19T16:49:07Z | - |
dc.date.issued | 2012 | - |
dc.identifier.issn | 0938-7994 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/90252 | - |
dc.description.abstract | OBJECTIVES: To investigate the effectiveness of qualitative diffusion-weighted imaging (DWI), subtraction of unenhanced from arterial phase images, and hepatobiliary phase (HBP) images in estimating the histopathological grade of hepatocellular carcinoma (HCC). METHODS: We retrospectively reviewed gadoxetic acid-enhanced magnetic resonance images of 175 patients with 201 surgically resected HCCs. The signal intensity and its relationship with histopathological grade were assessed for each sequence and a combination of sequences. RESULTS: There was a tendency towards higher grades in tumours showing restricted diffusion on DWI (P < 0.001) or arterial enhancement on subtraction imaging (P < 0.001), but not hepatocyte-defect on HBP images (P = 0.33). When lesions were divided into three groups based on combined findings on DWI and subtraction imaging, a linear trend was observed between group and grade (P < 0.001). The positive predictive value (PPV) of the combination of no restricted diffusion and no arterial enhancement in predicting well-differentiated HCC was 100%, higher than the PPV of individual findings on DWI (74%) or subtraction imaging (81%). CONCLUSIONS: DWI and subtraction imaging are helpful for predicting the histopathological grade of HCC, especially when the two sequences are considered together. KEY POINTS: • Predicting the histopathological grade of hepatocellular carcinoma (HCC) preoperatively is important. • Diffusion-weighted imaging (DWI) and subtraction imaging are recently developed MR techniques. • Retrospective study showed DWI and subtraction imaging helps predict HCC grades. • Management of patients with HCC becomes more appropriate. | - |
dc.description.statementOfResponsibility | open | - |
dc.relation.isPartOf | EUROPEAN RADIOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Carcinoma, Hepatocellular/diagnosis* | - |
dc.subject.MESH | Diffusion | - |
dc.subject.MESH | Diffusion Magnetic Resonance Imaging/methods* | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Gadolinium DTPA/pharmacology | - |
dc.subject.MESH | Hepatocytes/pathology | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Image Processing, Computer-Assisted/methods | - |
dc.subject.MESH | Liver Neoplasms/diagnosis* | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Observer Variation | - |
dc.subject.MESH | Predictive Value of Tests | - |
dc.subject.MESH | Reproducibility of Results | - |
dc.subject.MESH | Subtraction Technique | - |
dc.title | Prediction of the histopathological grade of hepatocellular carcinoma using qualitative diffusion-weighted, dynamic, and hepatobiliary phase MRI. | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Radiology (영상의학) | - |
dc.contributor.googleauthor | Chansik An | - |
dc.contributor.googleauthor | Mi-Suk Park | - |
dc.contributor.googleauthor | Hyae-Min Jeon | - |
dc.contributor.googleauthor | Yeo-Eun Kim | - |
dc.contributor.googleauthor | Woo-Suk Chung | - |
dc.contributor.googleauthor | Yong Eun Chung | - |
dc.contributor.googleauthor | Myeong-Jin Kim | - |
dc.contributor.googleauthor | Ki Whang Kim | - |
dc.identifier.doi | 22434421 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A00345 | - |
dc.contributor.localId | A00426 | - |
dc.contributor.localId | A00688 | - |
dc.contributor.localId | A01463 | - |
dc.contributor.localId | A03662 | - |
dc.contributor.localId | A03666 | - |
dc.relation.journalcode | J00851 | - |
dc.identifier.eissn | 1432-1084 | - |
dc.identifier.pmid | 22434421 | - |
dc.identifier.url | http://link.springer.com/article/10.1007%2Fs00330-012-2421-6 | - |
dc.subject.keyword | Hepatocellular carcinoma | - |
dc.subject.keyword | Gd-EOB-DTPA | - |
dc.subject.keyword | Diffusion-weighted MRI | - |
dc.subject.keyword | Subtraction technique | - |
dc.subject.keyword | Tumor grading | - |
dc.contributor.alternativeName | Kim, Ki Whang | - |
dc.contributor.alternativeName | Kim, Myeong Jin | - |
dc.contributor.alternativeName | Kim, Yeo Eun | - |
dc.contributor.alternativeName | Park, Mi Sook | - |
dc.contributor.alternativeName | Chung, Yong Eun | - |
dc.contributor.alternativeName | Chung, Woo Seok | - |
dc.contributor.affiliatedAuthor | Kim, Ki Whang | - |
dc.contributor.affiliatedAuthor | Kim, Myeong Jin | - |
dc.contributor.affiliatedAuthor | Kim, Yeo Eun | - |
dc.contributor.affiliatedAuthor | Park, Mi-Suk | - |
dc.contributor.affiliatedAuthor | Chung, Yong Eun | - |
dc.contributor.affiliatedAuthor | Chung, Woo Seok | - |
dc.citation.volume | 22 | - |
dc.citation.number | 8 | - |
dc.citation.startPage | 1701 | - |
dc.citation.endPage | 1708 | - |
dc.identifier.bibliographicCitation | EUROPEAN RADIOLOGY, Vol.22(8) : 1701-1708, 2012 | - |
dc.identifier.rimsid | 34094 | - |
dc.type.rims | ART | - |
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