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Prediction of the histopathological grade of hepatocellular carcinoma using qualitative diffusion-weighted, dynamic, and hepatobiliary phase MRI.

DC FieldValueLanguage
dc.contributor.author김기황-
dc.contributor.author김명진-
dc.contributor.author김여은-
dc.contributor.author박미숙-
dc.contributor.author정용은-
dc.contributor.author정우석-
dc.contributor.author안찬식-
dc.date.accessioned2014-12-19T16:49:07Z-
dc.date.available2014-12-19T16:49:07Z-
dc.date.issued2012-
dc.identifier.issn0938-7994-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/90252-
dc.description.abstractOBJECTIVES: To investigate the effectiveness of qualitative diffusion-weighted imaging (DWI), subtraction of unenhanced from arterial phase images, and hepatobiliary phase (HBP) images in estimating the histopathological grade of hepatocellular carcinoma (HCC). METHODS: We retrospectively reviewed gadoxetic acid-enhanced magnetic resonance images of 175 patients with 201 surgically resected HCCs. The signal intensity and its relationship with histopathological grade were assessed for each sequence and a combination of sequences. RESULTS: There was a tendency towards higher grades in tumours showing restricted diffusion on DWI (P < 0.001) or arterial enhancement on subtraction imaging (P < 0.001), but not hepatocyte-defect on HBP images (P = 0.33). When lesions were divided into three groups based on combined findings on DWI and subtraction imaging, a linear trend was observed between group and grade (P < 0.001). The positive predictive value (PPV) of the combination of no restricted diffusion and no arterial enhancement in predicting well-differentiated HCC was 100%, higher than the PPV of individual findings on DWI (74%) or subtraction imaging (81%). CONCLUSIONS: DWI and subtraction imaging are helpful for predicting the histopathological grade of HCC, especially when the two sequences are considered together. KEY POINTS: • Predicting the histopathological grade of hepatocellular carcinoma (HCC) preoperatively is important. • Diffusion-weighted imaging (DWI) and subtraction imaging are recently developed MR techniques. • Retrospective study showed DWI and subtraction imaging helps predict HCC grades. • Management of patients with HCC becomes more appropriate.-
dc.description.statementOfResponsibilityopen-
dc.relation.isPartOfEUROPEAN RADIOLOGY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdult-
dc.subject.MESHAged-
dc.subject.MESHCarcinoma, Hepatocellular/diagnosis*-
dc.subject.MESHDiffusion-
dc.subject.MESHDiffusion Magnetic Resonance Imaging/methods*-
dc.subject.MESHFemale-
dc.subject.MESHGadolinium DTPA/pharmacology-
dc.subject.MESHHepatocytes/pathology-
dc.subject.MESHHumans-
dc.subject.MESHImage Processing, Computer-Assisted/methods-
dc.subject.MESHLiver Neoplasms/diagnosis*-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHObserver Variation-
dc.subject.MESHPredictive Value of Tests-
dc.subject.MESHReproducibility of Results-
dc.subject.MESHSubtraction Technique-
dc.titlePrediction of the histopathological grade of hepatocellular carcinoma using qualitative diffusion-weighted, dynamic, and hepatobiliary phase MRI.-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Radiology (영상의학)-
dc.contributor.googleauthorChansik An-
dc.contributor.googleauthorMi-Suk Park-
dc.contributor.googleauthorHyae-Min Jeon-
dc.contributor.googleauthorYeo-Eun Kim-
dc.contributor.googleauthorWoo-Suk Chung-
dc.contributor.googleauthorYong Eun Chung-
dc.contributor.googleauthorMyeong-Jin Kim-
dc.contributor.googleauthorKi Whang Kim-
dc.identifier.doi22434421-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA00345-
dc.contributor.localIdA00426-
dc.contributor.localIdA00688-
dc.contributor.localIdA01463-
dc.contributor.localIdA03662-
dc.contributor.localIdA03666-
dc.relation.journalcodeJ00851-
dc.identifier.eissn1432-1084-
dc.identifier.pmid22434421-
dc.identifier.urlhttp://link.springer.com/article/10.1007%2Fs00330-012-2421-6-
dc.subject.keywordHepatocellular carcinoma-
dc.subject.keywordGd-EOB-DTPA-
dc.subject.keywordDiffusion-weighted MRI-
dc.subject.keywordSubtraction technique-
dc.subject.keywordTumor grading-
dc.contributor.alternativeNameKim, Ki Whang-
dc.contributor.alternativeNameKim, Myeong Jin-
dc.contributor.alternativeNameKim, Yeo Eun-
dc.contributor.alternativeNamePark, Mi Sook-
dc.contributor.alternativeNameChung, Yong Eun-
dc.contributor.alternativeNameChung, Woo Seok-
dc.contributor.affiliatedAuthorKim, Ki Whang-
dc.contributor.affiliatedAuthorKim, Myeong Jin-
dc.contributor.affiliatedAuthorKim, Yeo Eun-
dc.contributor.affiliatedAuthorPark, Mi-Suk-
dc.contributor.affiliatedAuthorChung, Yong Eun-
dc.contributor.affiliatedAuthorChung, Woo Seok-
dc.citation.volume22-
dc.citation.number8-
dc.citation.startPage1701-
dc.citation.endPage1708-
dc.identifier.bibliographicCitationEUROPEAN RADIOLOGY, Vol.22(8) : 1701-1708, 2012-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers

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