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The relationship between arterial stiffness and nonalcoholic fatty liver disease.

Authors
 Yong-Jae Lee  ;  Jae-Yong Shim  ;  Byung-Soo Moon  ;  Youn-Ho Shin  ;  Dong-Hyuk Jung  ;  Jung-Hyun Lee  ;  Hye-Ree Lee 
Citation
 DIGESTIVE DISEASES AND SCIENCES, Vol.57(1) : 196-203, 2012 
Journal Title
 DIGESTIVE DISEASES AND SCIENCES 
ISSN
 0163-2116 
Issue Date
2012
MeSH
Adult ; Aged ; Ankle Brachial Index ; Cardiovascular Diseases/epidemiology ; Fatty Liver/epidemiology* ; Female ; Humans ; Male ; Middle Aged ; Multivariate Analysis ; Non-alcoholic Fatty Liver Disease ; Prevalence ; Retrospective Studies ; Risk Factors ; Vascular Stiffness*
Keywords
Arterial stiffness ; Pulse wave velocity ; Nonalcoholic fatty liver disease ; Cardiovascular disease ; Inflammation
Abstract
AIM: Nonalcoholic fatty liver disease (NAFLD) is currently the most common form of chronic liver disease and some studies have documented its link with cardiovascular risk factors. This study aimed to investigate the association between arterial stiffness and NAFLD. METHODS: Among 1,442 health check-up subjects (955 men, 487 women), we examined the association between brachial-ankle pulse wave velocity (baPWV) as a measurement of arterial stiffness and the presence of NAFLD based on abdominal sonographic findings. Multivariate linear and logistic regression analyses were conducted to examine the independent association between baPWV and the presence of NAFLD in gender-specific manners. RESULTS: In multivariate regression analysis, NAFLD was found to be independently associated with baPWV in both men and women. Moreover, in multivariate logistic regression analysis, a graded independent relation was found between higher levels of baPWV and the prevalence risk of NAFLD. Odds ratios (95% CI) for the highest vs. the lowest quartile of baPWV were 1.85 (range, 1.13-2.62) in men and 3.32 (1.45-7.62) in women after adjusting for age, smoking status, regular exercise, body mass index, blood pressure, fasting plasma glucose, triglyceride, HDL-cholesterol, hypertension and diabetes. CONCLUSION: Arterial stiffness was independently associated with the prevalence risk for NAFLD regardless of classical CVD risk factors.
Full Text
http://link.springer.com/article/10.1007%2Fs10620-011-1819-3
DOI
21750929
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Family Medicine (가정의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Moon, Byung Soo(문병수)
Shim, Jae Yong(심재용) ORCID logo https://orcid.org/0000-0002-9561-9230
Lee, Yong Jae(이용제) ORCID logo https://orcid.org/0000-0002-6697-476X
Lee, Hye Ree(이혜리)
Jung, Dong Hyuk(정동혁) ORCID logo https://orcid.org/0000-0002-3411-0676
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/90141
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