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Metformin use is associated with a decreased incidence of colorectal adenomas in diabetic patients with previous colorectal cancer.

 Jin Ha Lee  ;  Soung Min Jeon  ;  Sung Pil Hong  ;  Jae Hee Cheon  ;  Tae Il Kim  ;  Won Ho Kim 
 DIGESTIVE AND LIVER DISEASE, Vol.44(12) : 1042-1047, 2012 
Journal Title
Issue Date
Adenoma/complications ; Adenoma/diagnosis ; Adenoma/epidemiology ; Adenoma/prevention & control* ; Adenomatous Polyps/complications ; Adenomatous Polyps/diagnosis ; Adenomatous Polyps/epidemiology ; Adenomatous Polyps/prevention & control ; Adult ; Aged ; Aged, 80 and over ; Colonoscopy ; Colorectal Neoplasms/complications ; Colorectal Neoplasms/diagnosis ; Colorectal Neoplasms/epidemiology ; Colorectal Neoplasms/prevention & control* ; Diabetes Mellitus, Type 2/complications ; Diabetes Mellitus, Type 2/drug therapy* ; Female ; Follow-Up Studies ; Humans ; Hypoglycemic Agents/therapeutic use* ; Incidence ; Male ; Metformin/therapeutic use* ; Middle Aged ; Neoplasms, Second Primary/complications ; Neoplasms, Second Primary/diagnosis ; Neoplasms, Second Primary/epidemiology ; Neoplasms, Second Primary/prevention & control* ; Population Surveillance ; Retrospective Studies ; Treatment Outcome
Colorectal adenoma ; Diabetes mellitus ; Incidence ; Metformin ; Previous Colorectal cancer
BACKGROUND: Metformin use has been associated with decreased cancer risk and mortality. However, the effects of metformin on the development of colorectal adenomas, the precursors of colorectal cancers, are not defined. AIMS: This study aimed to evaluate the potential effect of metformin on the incidence of colorectal adenomas in diabetic patients with previous colorectal cancer. METHODS: Among 488 consecutive diabetic patients who underwent colonoscopic surveillance after curative resection of colorectal cancer between 1998 and 2008, 240 patients were enrolled in this study and were compared in two groups: 114 patients taking metformin and 126 patients not taking metformin. Patient demographics, clinical characteristics, and colorectal adenoma incidence rate were analysed. RESULTS: After a median follow-up of 58 months, a total of 33 patients (28.9%) exhibited adenomatous colorectal polyps among the 114 patients who used metformin, compared with 58 (46.0%) patients with colorectal adenomas among the 126 patients who did not use metformin (odds ratio = 0.48, 95% confidence interval = 0.280-0.816, P = 0.008). After adjustment for clinically relevant factors, metformin use was found to be associated with a decreased incidence of colorectal adenomas (odds ratio = 0.27, 95% confidence interval = 0.100-0.758, P = 0.012) in diabetic patients with previous colorectal cancer. Metformin use in diabetic patients with previous colorectal cancer is associated with a lower risk of colorectal adenoma.
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1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Won Ho(김원호) ORCID logo https://orcid.org/0000-0002-5682-9972
Kim, Tae Il(김태일) ORCID logo https://orcid.org/0000-0003-4807-890X
Cheon, Jae Hee(천재희) ORCID logo https://orcid.org/0000-0002-2282-8904
Hong, Sung Pil(홍성필)
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