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Metformin use is associated with a decreased incidence of colorectal adenomas in diabetic patients with previous colorectal cancer.
DC Field | Value | Language |
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dc.contributor.author | 김원호 | - |
dc.contributor.author | 김태일 | - |
dc.contributor.author | 천재희 | - |
dc.contributor.author | 홍성필 | - |
dc.date.accessioned | 2014-12-19T16:45:31Z | - |
dc.date.available | 2014-12-19T16:45:31Z | - |
dc.date.issued | 2012 | - |
dc.identifier.issn | 1590-8658 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/90138 | - |
dc.description.abstract | BACKGROUND: Metformin use has been associated with decreased cancer risk and mortality. However, the effects of metformin on the development of colorectal adenomas, the precursors of colorectal cancers, are not defined. AIMS: This study aimed to evaluate the potential effect of metformin on the incidence of colorectal adenomas in diabetic patients with previous colorectal cancer. METHODS: Among 488 consecutive diabetic patients who underwent colonoscopic surveillance after curative resection of colorectal cancer between 1998 and 2008, 240 patients were enrolled in this study and were compared in two groups: 114 patients taking metformin and 126 patients not taking metformin. Patient demographics, clinical characteristics, and colorectal adenoma incidence rate were analysed. RESULTS: After a median follow-up of 58 months, a total of 33 patients (28.9%) exhibited adenomatous colorectal polyps among the 114 patients who used metformin, compared with 58 (46.0%) patients with colorectal adenomas among the 126 patients who did not use metformin (odds ratio = 0.48, 95% confidence interval = 0.280-0.816, P = 0.008). After adjustment for clinically relevant factors, metformin use was found to be associated with a decreased incidence of colorectal adenomas (odds ratio = 0.27, 95% confidence interval = 0.100-0.758, P = 0.012) in diabetic patients with previous colorectal cancer. Metformin use in diabetic patients with previous colorectal cancer is associated with a lower risk of colorectal adenoma. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 1042~1047 | - |
dc.relation.isPartOf | DIGESTIVE AND LIVER DISEASE | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adenoma/complications | - |
dc.subject.MESH | Adenoma/diagnosis | - |
dc.subject.MESH | Adenoma/epidemiology | - |
dc.subject.MESH | Adenoma/prevention & control* | - |
dc.subject.MESH | Adenomatous Polyps/complications | - |
dc.subject.MESH | Adenomatous Polyps/diagnosis | - |
dc.subject.MESH | Adenomatous Polyps/epidemiology | - |
dc.subject.MESH | Adenomatous Polyps/prevention & control | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Aged, 80 and over | - |
dc.subject.MESH | Colonoscopy | - |
dc.subject.MESH | Colorectal Neoplasms/complications | - |
dc.subject.MESH | Colorectal Neoplasms/diagnosis | - |
dc.subject.MESH | Colorectal Neoplasms/epidemiology | - |
dc.subject.MESH | Colorectal Neoplasms/prevention & control* | - |
dc.subject.MESH | Diabetes Mellitus, Type 2/complications | - |
dc.subject.MESH | Diabetes Mellitus, Type 2/drug therapy* | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Follow-Up Studies | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Hypoglycemic Agents/therapeutic use* | - |
dc.subject.MESH | Incidence | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Metformin/therapeutic use* | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Neoplasms, Second Primary/complications | - |
dc.subject.MESH | Neoplasms, Second Primary/diagnosis | - |
dc.subject.MESH | Neoplasms, Second Primary/epidemiology | - |
dc.subject.MESH | Neoplasms, Second Primary/prevention & control* | - |
dc.subject.MESH | Population Surveillance | - |
dc.subject.MESH | Retrospective Studies | - |
dc.subject.MESH | Treatment Outcome | - |
dc.title | Metformin use is associated with a decreased incidence of colorectal adenomas in diabetic patients with previous colorectal cancer. | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학) | - |
dc.contributor.googleauthor | Jin Ha Lee | - |
dc.contributor.googleauthor | Soung Min Jeon | - |
dc.contributor.googleauthor | Sung Pil Hong | - |
dc.contributor.googleauthor | Jae Hee Cheon | - |
dc.contributor.googleauthor | Tae Il Kim | - |
dc.contributor.googleauthor | Won Ho Kim | - |
dc.identifier.doi | 22789400 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A00774 | - |
dc.contributor.localId | A01079 | - |
dc.contributor.localId | A04404 | - |
dc.contributor.localId | A04030 | - |
dc.relation.journalcode | J00735 | - |
dc.identifier.eissn | 1878-3562 | - |
dc.identifier.pmid | 22789400 | - |
dc.identifier.url | http://www.sciencedirect.com/science/article/pii/S1590865812002125 | - |
dc.subject.keyword | Colorectal adenoma | - |
dc.subject.keyword | Diabetes mellitus | - |
dc.subject.keyword | Incidence | - |
dc.subject.keyword | Metformin | - |
dc.subject.keyword | Previous Colorectal cancer | - |
dc.contributor.alternativeName | Kim, Won Ho | - |
dc.contributor.alternativeName | Kim, Tae Il | - |
dc.contributor.alternativeName | Cheon, Jae Hee | - |
dc.contributor.alternativeName | Hong, Sung Pil | - |
dc.contributor.affiliatedAuthor | Kim, Won Ho | - |
dc.contributor.affiliatedAuthor | Kim, Tae Il | - |
dc.contributor.affiliatedAuthor | Hong, Sung Pil | - |
dc.contributor.affiliatedAuthor | Cheon, Jae Hee | - |
dc.citation.volume | 44 | - |
dc.citation.number | 12 | - |
dc.citation.startPage | 1042 | - |
dc.citation.endPage | 1047 | - |
dc.identifier.bibliographicCitation | DIGESTIVE AND LIVER DISEASE, Vol.44(12) : 1042-1047, 2012 | - |
dc.identifier.rimsid | 32383 | - |
dc.type.rims | ART | - |
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