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Association of soluble receptor for advanced glycation end-product with increasing central aortic stiffness in hypertensive patients.

 Yoon, Se-Jung  ;  Park, Sungha  ;  Park, Chanmi  ;  Chang, Woochul  ;  Cho, Deok-Kyu  ;  Ko, Young-Guk  ;  Choi, Dong hoon  ;  Kwon, Hyuck Moon  ;  Jang, Yangsoo  ;  Chung, Nam sik 
 CORONARY ARTERY DISEASE, Vol.23(2) : 85-90, 2012 
Journal Title
Issue Date
Biomarkers/blood ; Blood Pressure/physiology ; Electrocardiography ; Enzyme-Linked Immunosorbent Assay ; Female ; Follow-Up Studies ; Glycation End Products, Advanced ; Humans ; Hypertension/blood* ; Hypertension/physiopathology ; Male ; Middle Aged ; Receptor for Advanced Glycation End Products ; Receptors, Immunologic/blood* ; Severity of Illness Index ; Vascular Stiffness/physiology*
dvanced glycation end-product ; aortic stiffness ; hypertension ; soluble receptor for advanced glycation end-product
OBJECTIVES: In humans, a secreted isoform of (soluble) receptor for advanced glycation end-products (sRAGE) may act as a decoy receptor of advanced glycation end-product. The level of sRAGE may reflect the activity of cell surface receptor for advanced glycation end-product. But there has been no study that has demonstrated the association of sRAGE with central aortic stiffness. Here, we studied the relation of plasma sRAGE level and arterial pulse wave velocity in hypertensive patients. MATERIALS AND METHODS: A total of 415 patients were enrolled (men; 57.6%, mean age; 53.2±10.8 years), with 25.8% (n=107) of these being diabetic. All patients underwent pulse wave velocity (PWV) and blood sampling of sRAGE, high-sensitive C-reactive protein, and other serologic markers. RESULTS: The log-transformed sRAGE was significantly correlated with the marker of central aortic stiffness heart to femoral PWV (hfPWV; r=0.165, P=0.001). It also showed a significant correlation with hfPWV in patients with diabetes (r=0.301, P=0.002), but not in patients without diabetes (r=0.115, P=0.055). By multiple linear regression analysis, the log-transformed sRAGE was independently correlated with hfPWV (β=0.13, P=0.004) when controlled for other variables. CONCLUSIONS: This study has demonstrated, for the first time, that serum sRAGE level was independently correlated with a marker of central aortic stiffness. This result suggests the potential role of RAGE in the pathogenesis of aortic stiffness.
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1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Biomedical Systems Informatics (의생명시스템정보학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Medical Research Center (임상의학연구센터) > 1. Journal Papers
Yonsei Authors
Ko, Young Guk(고영국) ORCID logo https://orcid.org/0000-0001-7748-5788
Kwon, Hyuck Moon(권혁문) ORCID logo https://orcid.org/0000-0001-9901-5015
Park, Sung Ha(박성하) ORCID logo https://orcid.org/0000-0001-5362-478X
Park, Chan Mi(박찬미)
Jang, Yang Soo(장양수) ORCID logo https://orcid.org/0000-0002-2169-3112
Chang, Woo Chul(장우철)
Chung, Nam Sik(정남식)
Cho, Deok Kyu(조덕규)
Choi, Dong Hoon(최동훈) ORCID logo https://orcid.org/0000-0002-2009-9760
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