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Comparison of vascular remodeling in patients treated with sirolimus-versus zotarolimus-eluting stent following acute myocardial infarction.

Authors
 Ki-Woon Kang  ;  Young-Guk Ko  ;  Dong-Ho Shin  ;  Jung-Sun Kim  ;  Byeong-Keuk Kim  ;  Donghoon Choi  ;  Yangsoo Jang  ;  Myeong-Ki Hong 
Citation
 CLINICAL CARDIOLOGY, Vol.35(1) : 49-54, 2012 
Journal Title
 CLINICAL CARDIOLOGY 
ISSN
 0160-9289 
Issue Date
2012
MeSH
Angioplasty, Balloon, Coronary ; Coronary Angiography ; Coronary Vessels/pathology* ; Drug-Eluting Stents* ; Female ; Follow-Up Studies ; Humans ; Male ; Myocardial Infarction/pathology ; Myocardial Infarction/therapy* ; Neointima/pathology* ; Sirolimus/analogs & derivatives* ; Sirolimus/therapeutic use* ; Treatment Outcome ; Ultrasonography, Interventional
Keywords
Angioplasty, Balloon, Coronary ; Coronary Angiography ; Coronary Vessels/pathology* ; Drug-Eluting Stents* ; Female ; Follow-Up Studies ; Humans ; Male ; Myocardial Infarction/pathology ; Myocardial Infarction/therapy* ; Neointima/pathology* ; Sirolimus/analogs & derivatives* ; Sirolimus/therapeutic use* ; Treatment Outcome ; Ultrasonography, Interventional
Abstract
BACKGROUND: The differences in the vascular response to stent implantation or in the incidence of late acquired stent malapposition among different types of drug-eluting stents are not well known in patients with acute myocardial infarction (MI). HYPOTHESIS: The pattern of vascular remodeling and degree of neointimal proliferation were different depending on the different types of drug-eluting stents. METHODS: This study used intravascular ultrasound (IVUS) to investigate vascular remodeling in patients treated with implantation of sirolimus-eluting stents (SESs) vs zotarolimus-eluting stents (ZESs) following acute MI. The study population consisted of 100 patients with acute MI who were treated either with SES (n = 41) or ZES (n = 59) and underwent both poststenting and 9-month follow-up IVUS examination. Serial vascular changes surrounding stented segments were compared between SES- and ZES-treated lesions. RESULTS: Percentage of neointimal volume obstruction at follow-up was significantly smaller in SES-treated compared to ZES-treated lesions (2.8 ± 7.1% vs 18.1 ± 15.7%, respectively; P < 0.001). However, positive vascular remodeling, which was defined as greater than 10% increase in external elastic membrane volume index (31.7% vs 10.2%, respectively, P = 0.007), and late acquired stent malapposition (12.0% vs 0%, respectively, P = 0.006 ) occurred more frequently in SES-treated than in ZES-treated lesions. CONCLUSIONS: The pattern of vascular remodeling, including positive remodeling, late acquired stent malapposition, and degree of neointimal proliferation might be different depending on the different types of drug-eluting stents in patients with acute MI.
Full Text
http://onlinelibrary.wiley.com/doi/10.1002/clc.20988/abstract
DOI
22161864
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Kang, Ki Woon(강기운)
Ko, Young Guk(고영국) ORCID logo https://orcid.org/0000-0001-7748-5788
Kim, Byeong Keuk(김병극) ORCID logo https://orcid.org/0000-0003-2493-066X
Kim, Jung Sun(김중선) ORCID logo https://orcid.org/0000-0003-2263-3274
Shin, Dong Ho(신동호) ORCID logo https://orcid.org/0000-0002-7874-5542
Jang, Yang Soo(장양수) ORCID logo https://orcid.org/0000-0002-2169-3112
Choi, Dong Hoon(최동훈) ORCID logo https://orcid.org/0000-0002-2009-9760
Hong, Myeong Ki(홍명기) ORCID logo https://orcid.org/0000-0002-2090-2031
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/90012
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