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A facile approach for the delivery of inorganic nanoparticles into the brain by passing through the blood-brain barrier (BBB).

Authors
 Yeong Shin Yim  ;  Jin-sil Choi  ;  Gun Tae Kim  ;  Chul Hoon Kim  ;  Tae-Hyun Shin  ;  Dong Goo Kim  ;  Jinwoo Cheon 
Citation
 CHEMICAL COMMUNICATIONS, Vol.48(1) : 61-63, 2012 
Journal Title
CHEMICAL COMMUNICATIONS
ISSN
 1359-7345 
Issue Date
2012
MeSH
Animals ; Astrocytes/metabolism ; Biological Transport ; Blood-Brain Barrier/metabolism* ; Endothelial Cells/metabolism ; Ferric Compounds/chemistry* ; Ferric Compounds/metabolism* ; Mice ; Nanoparticles/chemistry* ; Neurons/metabolism ; Permeability ; Serum Albumin/chemistry* ; Serum Albumin/metabolism*
Keywords
Animals ; Astrocytes/metabolism ; Biological Transport ; Blood-Brain Barrier/metabolism* ; Endothelial Cells/metabolism ; Ferric Compounds/chemistry* ; Ferric Compounds/metabolism* ; Mice ; Nanoparticles/chemistry* ; Neurons/metabolism ; Permeability ; Serum Albumin/chemistry* ; Serum Albumin/metabolism*
Abstract
This study provides an easy and simple method to obtain inorganic nanoparticles that can penetrate the blood-brain barrier, the heavily guarded system in the brain, via cross-linked serum albumin surface coatings. Their intact BBB permeability was confirmed in both in vitro and in vivo tests.
Full Text
http://pubs.rsc.org/en/Content/ArticleLanding/2012/CC/c1cc15113d
DOI
22057099
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pharmacology (약리학교실) > 1. Journal Papers
Yonsei Authors
Kim, Dong Goo(김동구)
Kim, Chul Hoon(김철훈) ORCID logo https://orcid.org/0000-0002-7360-429X
Yim, Yeong Shin(임영신)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/89938
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