1 261

Cited 23 times in

Aortic calcification and bone metabolism: the relationship between aortic calcification, BMD, vertebral fracture, 25-hydroxyvitamin D, and osteocalcin.

DC FieldValueLanguage
dc.contributor.author박경혜-
dc.contributor.author오선민-
dc.contributor.author이용호-
dc.contributor.author이유미-
dc.contributor.author임승길-
dc.contributor.author차봉수-
dc.contributor.author김경민-
dc.contributor.author최한석-
dc.contributor.author김명진-
dc.contributor.author김광준-
dc.date.accessioned2014-12-19T16:36:15Z-
dc.date.available2014-12-19T16:36:15Z-
dc.date.issued2012-
dc.identifier.issn0171-967X-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/89842-
dc.description.abstractThe aim of this study was to investigate the relationship between aortic calcification (AC) and low bone mineral density (BMD), 25(OH)D, C-terminal telopeptide (CTx), and osteocalcin levels in Asian women. We also tried to find the association between AC and the risk of vertebral fracture. We included 769 patients in this study. All patients underwent QCT. Aortic calcium score (ACS) was quantified by the Agatston scoring method. Spinal fracture was defined by lumbar spine radiography. Among 769 subjects, 96 had at least one vertebral fracture and 345 had AC. ACS positively correlated with age. Osteocalcin, CTx, 25(OH)D, total-hip trabecular BMD (tBMD), femoral neck tBMD, and vertebral tBMD were inversely related with ACS. However, cortical BMD (cBMD) did not correlate with ACS. Among these parameters, only osteocalcin significantly correlated with ACS, even after adjusting for age. We divided the subjects into two groups based on the presence of AC to determine the association between AC and vertebral fracture. Multivariate logistic regression analysis showed that age, tBMD of each site, and AC were associated with vertebral fractures. After adjusting for confounding factors, patients with AC had more than a threefold increased risk of vertebral fracture (OR = 3.29-3.57, P < 0.05 according to site). This study suggests that high ACS is related to low tBMD but not cBMD. Furthermore, our findings indicate that this relationship is definitely age-dependent. Finally, we found that AC is significantly associated with the prevalence of vertebral fracture in Asian women.-
dc.description.statementOfResponsibilityopen-
dc.format.extent370~378-
dc.relation.isPartOfCALCIFIED TISSUE INTERNATIONAL-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.titleAortic calcification and bone metabolism: the relationship between aortic calcification, BMD, vertebral fracture, 25-hydroxyvitamin D, and osteocalcin.-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Preventive Medicine (예방의학)-
dc.contributor.googleauthorKim, Kwang Joon-
dc.contributor.googleauthorKim, Kyoung Min-
dc.contributor.googleauthorPark, Kyeong Hye-
dc.contributor.googleauthorChoi, Han Seok-
dc.contributor.googleauthorRhee, Yumie-
dc.identifier.doi10.1007/s00223-012-9642-1-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA01425-
dc.contributor.localIdA02373-
dc.contributor.localIdA02989-
dc.contributor.localIdA03012-
dc.contributor.localIdA03375-
dc.contributor.localIdA03996-
dc.contributor.localIdA00295-
dc.contributor.localIdA04206-
dc.contributor.localIdA00426-
dc.contributor.localIdA00317-
dc.relation.journalcodeJ00425-
dc.identifier.eissn1432-0827-
dc.identifier.pmidAortic calcification ; Asian ; QCT ; vBMD ; Vertebral fracture-
dc.identifier.urlhttp://link.springer.com/article/10.1007%2Fs00223-012-9642-1-
dc.subject.keywordAortic calcification-
dc.subject.keywordAsian-
dc.subject.keywordQCT-
dc.subject.keywordvBMD-
dc.subject.keywordVertebral fracture-
dc.contributor.alternativeNamePark, Kyeong Hye-
dc.contributor.alternativeNameOh, Sun Min-
dc.contributor.alternativeNameLee, Yong Ho-
dc.contributor.alternativeNameRhee, Yumie-
dc.contributor.alternativeNameLim, Sung Kil-
dc.contributor.alternativeNameCha, Bong Soo-
dc.contributor.alternativeNameKim, Kyung Min-
dc.contributor.alternativeNameChoi, Han Seok-
dc.contributor.alternativeNameKim, Myeong Jin-
dc.contributor.affiliatedAuthorPark, Kyeong Hye-
dc.contributor.affiliatedAuthorOh, Sun Min-
dc.contributor.affiliatedAuthorLee, Yong Ho-
dc.contributor.affiliatedAuthorRhee, Yumie-
dc.contributor.affiliatedAuthorLim, Sung Kil-
dc.contributor.affiliatedAuthorCha, Bong Soo-
dc.contributor.affiliatedAuthorKim, Kyung Min-
dc.contributor.affiliatedAuthorChoi, Han Seok-
dc.contributor.affiliatedAuthorKim, Myeong Jin-
dc.contributor.affiliatedAuthorKim, Kwang Joon-
dc.citation.volume91-
dc.citation.number6-
dc.citation.startPage370-
dc.citation.endPage378-
dc.identifier.bibliographicCitationCALCIFIED TISSUE INTERNATIONAL, Vol.91(6) : 370-378, 2012-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Preventive Medicine and Public Health (예방의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.